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Protein

60 kDa chaperonin

Gene

groL

Organism
Clostridioides difficile (Peptoclostridium difficile)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • adhesion of symbiont to host cell Source: CACAO
  • hyperosmotic salinity response Source: CAFA
  • protein refolding Source: InterPro
  • response to acidic pH Source: CAFA
  • response to heat Source: CAFA
  • response to iron ion starvation Source: CAFA

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
OrganismiClostridioides difficile (Peptoclostridium difficile)
Taxonomic identifieri1496 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptostreptococcaceaeClostridioides

Subcellular locationi

Q9KKF0:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cell surface Source: CAFA
  • cell wall Source: CAFA
  • cytoplasm Source: CAFA
  • extracellular space Source: CAFA
  • plasma membrane Source: CAFA

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633401 – 54060 kDa chaperoninAdd BLAST540

Proteomic databases

PRIDEiQ9KKF0.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9KKF0.
SMRiQ9KKF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJ9. Bacteria.
COG0459. LUCA.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KKF0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIKFSEE TRRALEAGVN KLADTVKVTL GPKGRNVILD KKFGSPLITN
60 70 80 90 100
DGVTIAKEIE LEDRFENMGA QLVKEVATKT NDVAGDGTTT ATVLAQAIIR
110 120 130 140 150
EGLKNVTAGA NPILLRKGIQ KAVTVAVEEL KNQSRIVETQ EAISQVASIS
160 170 180 190 200
AGDEEVGKLI AEAMEIVGKD GVITVEESQT MNTELDAVEG MQFDRGFVSA
210 220 230 240 250
YMVTDVDKME AVLNDPYILI TDKKISNIQE LLPVLEQIVQ QGKKLLIIAE
260 270 280 290 300
DVEGEALSTL VVNKLRGTFD VVAVKAPGFG DRRKEMLQDI AILTGAQVIS
310 320 330 340 350
EELGYDLKEA DLSMLGRASS VKVTKESTTI VDGSGDKKAI EDRVTQIKHQ
360 370 380 390 400
VEQTTSDFDR EKLMERLAKL AGGVAVVKVG AATEVELKER KLRIEDALNA
410 420 430 440 450
TRAAVEEGIV AGGGTAFVSV IPAIGTLIES LEGEVKLGAQ IVKKALEEPL
460 470 480 490 500
RQIAINAGLE GAVIVQNVVN SEAETGFDAL NEKYVNMIEA GIVDPTKVSR
510 520 530 540
SALQNAASIA STFLTTEAAV ADLPEKEDAG MPGTGMDGMY
Length:540
Mass (Da):57,677
Last modified:October 1, 2000 - v1
Checksum:i7D19C198D1091166
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti214N → K in strain: ATCC 43603. 1
Natural varianti235L → V in strain: ATCC 43603. 1
Natural varianti327S → N in strain: ATCC 43603. 1
Natural varianti339A → S in strain: ATCC 43603. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF080547 Genomic DNA. Translation: AAF73984.1.
AF159449 Genomic DNA. Translation: AAF80372.1.

Similar proteinsi

Entry informationi

Entry nameiCH60_CLODI
AccessioniPrimary (citable) accession number: Q9KKF0
Secondary accession number(s): Q9KJV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families