Q9KJC4 (ARPR_PSEPU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable HTH-type transcriptional regulator ArpR

Alternative name(s):
Antibiotic efflux pump ArpABC operon regulator

Gene names

Name:

arpR

Organism

Pseudomonas putida (Arthrobacter siderocapsulatus)

Taxonomic identifier

303 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › Pseudomonas putida group

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor By similarity.
Sequence similarities	Contains 1 HTH tetR-type DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Probable HTH-type transcriptional regulator ArpR		PRO_0000070624
Regions
	Domain	10 – 70	61	HTH tetR-type
	DNA binding	33 – 52	20	H-T-H motif Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9KJC4 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: A167F57269CC2F91	FASTA	210	23,797
	10 20 30 40 50 60 MVRRTKEEAQ ETRAQIIEAA ERAFYKRGVA RTTLADIAEL AGVTRGAIYW HFNNKAELVQ 70 80 90 100 110 120 ALLDSLHETH DHLARASESE DELDPLGCMR KLLLQVFNEL VLDARTRRIN EILHHKCEFT 130 140 150 160 170 180 DDMCEIRQQR QSAVLDCHKG ITLALANAVR RGQLPGELDV ERAAVAMFAY VDGLIGRWLL 190 200 210 LPDSVDLLGD VEKWVDTGLD MLRLSPALRK

References

[1]	"Identification and molecular characterization of an efflux system involved in Pseudomonas putida S12 multidrug resistance." Kieboom J., de Bont J.A.M. Microbiology 147:43-51(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 700801 / S12.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF183959 Genomic DNA. Translation: AAF73830.1.
3D structure databases
ProteinModelPortal	Q9KJC4.
SMR	Q9KJC4. Positions 5-210.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.10.60. 2 hits. 1.10.357.10. 1 hit.
InterPro	IPR023772. DNA-bd_HTH_TetR-type_CS. IPR009057. Homeodomain-like. IPR001647. HTH_TetR. IPR015893. Tet_transcr_reg_TetR-like_C. IPR011075. Tet_transcr_reg_TetR-rel_C. IPR013572. Tscrpt_reg_MAATS_C. [Graphical view]
Pfam	PF08361. TetR_C_2. 1 hit. PF00440. TetR_N. 1 hit. [Graphical view]
PRINTS	PR00455. HTHTETR.
SUPFAM	SSF46689. Homeodomain_like. 1 hit. SSF48498. TetR_like_C. 1 hit.
PROSITE	PS01081. HTH_TETR_1. 1 hit. PS50977. HTH_TETR_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARPR_PSEPU

Accession

Primary (citable) accession number: Q9KJC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program