Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9KJB0

- BLAB6_ELIME

UniProt

Q9KJB0 - BLAB6_ELIME

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Carbapenem-hydrolyzing beta-lactamase BlaB-6

Gene

blaB6

Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate.By similarity

Catalytic activityi

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Zinc 1By similarity
Metal bindingi99 – 991Zinc 1By similarity
Metal bindingi101 – 1011Zinc 2By similarity
Metal bindingi160 – 1601Zinc 1By similarity
Metal bindingi179 – 1791Zinc 2By similarity
Metal bindingi221 – 2211Zinc 2By similarity

GO - Molecular functioni

  1. beta-lactamase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. antibiotic catabolic process Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Carbapenem-hydrolyzing beta-lactamase BlaB-6 (EC:3.5.2.6)
Short name:
CHbetaL-6
Alternative name(s):
Class B carbapenemase BlaB-6
Gene namesi
Name:blaB6
Synonyms:blaB
OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifieri238 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 248227Carbapenem-hydrolyzing beta-lactamase BlaB-6PRO_0000016954Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9KJB0.
SMRiQ9KJB0. Positions 26-244.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamiPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KJB0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRLKGLLVL ALGFTGLQVF GQQNPDIKIE KLKDNLYVYT TYNTFKGTKY
60 70 80 90 100
AANAVYMVTD KGVVVIDSPW GEDKFKSFTD EIYKKHGKKV IMNIATHSHD
110 120 130 140 150
DRAGGLEYFG KLGAKTYSTK MTDSILAKEN KPRAKYTFDN NKSFKVGNTE
160 170 180 190 200
FQVYYPGKGH TADNVVVWFP KDKVLVGGCI VKSGDSKDLG FIGEAYVNDW
210 220 230 240
TQSIHNIQQK FPDVQYVVAG HDDWKDQTSI QHTLDLISEY QQKQKASN
Length:248
Mass (Da):28,046
Last modified:October 1, 2000 - v1
Checksum:i720CF80F4A1EA837
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189302 Genomic DNA. Translation: AAF89158.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF189302 Genomic DNA. Translation: AAF89158.1 .

3D structure databases

ProteinModelPortali Q9KJB0.
SMRi Q9KJB0. Positions 26-244.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.60.15.10. 1 hit.
InterProi IPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view ]
Pfami PF00753. Lactamase_B. 1 hit.
[Graphical view ]
SMARTi SM00849. Lactamase_B. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 1 hit.
PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
    Bellais S., Aubert D., Naas T., Nordmann P.
    Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: NCTC 11305 / CIP 78.30.

Entry informationi

Entry nameiBLAB6_ELIME
AccessioniPrimary (citable) accession number: Q9KJB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3