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Q9KJA9

- BLAB5_ELIME

UniProt

Q9KJA9 - BLAB5_ELIME

Protein

Carbapenem-hydrolyzing beta-lactamase BlaB-5

Gene

blaB5

Organism
Elizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate.By similarity

    Catalytic activityi

    A beta-lactam + H2O = a substituted beta-amino acid.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi98 – 981Zinc 1By similarity
    Metal bindingi100 – 1001Zinc 1By similarity
    Metal bindingi102 – 1021Zinc 2By similarity
    Metal bindingi161 – 1611Zinc 1By similarity
    Metal bindingi180 – 1801Zinc 2By similarity
    Metal bindingi222 – 2221Zinc 2By similarity

    GO - Molecular functioni

    1. beta-lactamase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. antibiotic catabolic process Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbapenem-hydrolyzing beta-lactamase BlaB-5 (EC:3.5.2.6)
    Short name:
    CHbetaL-5
    Alternative name(s):
    Class B carbapenemase BlaB-5
    Gene namesi
    Name:blaB5
    Synonyms:blaB
    OrganismiElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
    Taxonomic identifieri238 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222By similarityAdd
    BLAST
    Chaini23 – 249227Carbapenem-hydrolyzing beta-lactamase BlaB-5PRO_0000016953Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KJA9.
    SMRiQ9KJA9. Positions 27-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.60.15.10. 1 hit.
    InterProiIPR001279. Beta-lactamas-like.
    IPR001018. Beta-lactamase_class-B_CS.
    [Graphical view]
    PfamiPF00753. Lactamase_B. 1 hit.
    [Graphical view]
    SMARTiSM00849. Lactamase_B. 1 hit.
    [Graphical view]
    SUPFAMiSSF56281. SSF56281. 1 hit.
    PROSITEiPS00743. BETA_LACTAMASE_B_1. 1 hit.
    PS00744. BETA_LACTAMASE_B_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9KJA9-1 [UniParc]FASTAAdd to Basket

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    MLKRLKGLLV LALGFTGLQV FGQQNPDIKI EKLKDNLYVY TTYNTFKGTK    50
    YAANAVYMVT DKGVVVIDSP WGEDKFKSFT DEIYKKHGKK VIMNIATHSH 100
    DDRAGGLEYF GKLGAKTYST KMTDSILAKE NKPRAKYTFD NNKSFKVGNT 150
    EFQVYYPGKG HTADNVVVWF PKDKVLVGGC IVKSGDSKDL GYIGEAYVND 200
    WTQSIHNIQQ KFPDVQYVVA GHDDWKDQTS IQHTLDLISD YQQKQKASN 249
    Length:249
    Mass (Da):28,161
    Last modified:October 1, 2000 - v1
    Checksum:i252BA20FCEF1A837
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189303 Genomic DNA. Translation: AAF89159.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF189303 Genomic DNA. Translation: AAF89159.1 .

    3D structure databases

    ProteinModelPortali Q9KJA9.
    SMRi Q9KJA9. Positions 27-245.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.60.15.10. 1 hit.
    InterProi IPR001279. Beta-lactamas-like.
    IPR001018. Beta-lactamase_class-B_CS.
    [Graphical view ]
    Pfami PF00753. Lactamase_B. 1 hit.
    [Graphical view ]
    SMARTi SM00849. Lactamase_B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56281. SSF56281. 1 hit.
    PROSITEi PS00743. BETA_LACTAMASE_B_1. 1 hit.
    PS00744. BETA_LACTAMASE_B_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
      Bellais S., Aubert D., Naas T., Nordmann P.
      Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: NCTC 11306 / CIP 79.5.

    Entry informationi

    Entry nameiBLAB5_ELIME
    AccessioniPrimary (citable) accession number: Q9KJA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3