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Q9KJA8 (BLAB7_ELIME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Carbapenem-hydrolyzing beta-lactamase BlaB-7

Short name=CHbetaL-7
EC=3.5.2.6
Alternative name(s):
Class B carbapenemase BlaB-7
Gene names
Name:blaB7
Synonyms:blaB
OrganismElizabethkingia meningoseptica (Chryseobacterium meningosepticum)
Taxonomic identifier238 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeElizabethkingia

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes penicillins, cephalosporins (including cefoxitin), carbapenems and 6-beta-iodopenicillanate By similarity.

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.

Ontologies

Keywords
   Biological processAntibiotic resistance
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processantibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionbeta-lactamase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 248227Carbapenem-hydrolyzing beta-lactamase BlaB-7
PRO_0000016955

Sites

Metal binding971Zinc 1 By similarity
Metal binding991Zinc 1 By similarity
Metal binding1011Zinc 2 By similarity
Metal binding1601Zinc 1 By similarity
Metal binding1791Zinc 2 By similarity
Metal binding2211Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KJA8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C1DD1743CF858A9A

FASTA24827,975
        10         20         30         40         50         60 
MKGLKGLLVL ALGFTGLQVF GQQNPDIKIE KLKDNLYVYT TYNTFKGTKY AANAVYMVTD 

        70         80         90        100        110        120 
KGIVVIDSPW GEDKFKSFTD EIYKKHGKKV IMNIATHSHD DRAGGLEYFG KLGAKTYSTK 

       130        140        150        160        170        180 
MTDSILAKEN KPRAKYTFDN NKSFKVGKTE FQVYYPGKGH TADNVVVWFP KDKVLVGGCI 

       190        200        210        220        230        240 
VKSGDSKDLG FIGEAYVNDW TQSIHNIQQK FPDVQYVVAG HDDWKDQTSI QHTLDLISEY 


QQKQKASN 

« Hide

References

[1]"Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum."
Bellais S., Aubert D., Naas T., Nordmann P.
Antimicrob. Agents Chemother. 44:1878-1886(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: AB1572.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF189304 Genomic DNA. Translation: AAF89160.1.

3D structure databases

ProteinModelPortalQ9KJA8.
SMRQ9KJA8. Positions 26-244.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.60.15.10. 1 hit.
InterProIPR001279. Beta-lactamas-like.
IPR001018. Beta-lactamase_class-B_CS.
[Graphical view]
PfamPF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMSSF56281. SSF56281. 1 hit.
PROSITEPS00743. BETA_LACTAMASE_B_1. 1 hit.
PS00744. BETA_LACTAMASE_B_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBLAB7_ELIME
AccessionPrimary (citable) accession number: Q9KJA8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families