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Protein

Cytochrome P450 167A1

Gene

cyp167A1

Organism
Sorangium cellulosum (Polyangium cellulosum)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of epothilones, macrolactones which have a narrow anti-fungal spectrum and microtubule-stabilizing activity. Responsible for the epooxidation of epothilones C and D to epothilones A and B, respectively.1 Publication

Catalytic activityi

epothilone C + AH2 + O2 = epothilone A + A + H2O.1 Publication
epothilone D + AH2 + O2 = epothilone B + A + H2O.1 Publication

Cofactori

Pathwayi: epothilone biosynthesis

This protein is involved in the pathway epothilone biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway epothilone biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi365Iron (heme axial ligand)1

GO - Molecular functioni

GO - Biological processi

  • epothilone biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00774.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 167A1 (EC:1.14.-.-)
Alternative name(s):
Cytochrome P450epoK
Epothilone epoxidase
Gene namesi
Name:cyp167A1
Synonyms:epoF, epoK
OrganismiSorangium cellulosum (Polyangium cellulosum)Imported
Taxonomic identifieri56 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesSorangiineaePolyangiaceaeSorangium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000522411 – 419Cytochrome P450 167A1Add BLAST419

Structurei

Secondary structure

1419
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni22 – 26Combined sources5
Helixi29 – 38Combined sources10
Beta strandi40 – 44Combined sources5
Turni45 – 48Combined sources4
Beta strandi49 – 52Combined sources4
Helixi55 – 62Combined sources8
Helixi71 – 73Combined sources3
Helixi77 – 82Combined sources6
Helixi85 – 87Combined sources3
Helixi88 – 93Combined sources6
Turni95 – 97Combined sources3
Helixi100 – 110Combined sources11
Helixi111 – 114Combined sources4
Helixi116 – 119Combined sources4
Helixi120 – 122Combined sources3
Helixi123 – 137Combined sources15
Turni145 – 149Combined sources5
Helixi150 – 152Combined sources3
Helixi154 – 161Combined sources8
Helixi166 – 168Combined sources3
Helixi169 – 182Combined sources14
Turni183 – 187Combined sources5
Helixi195 – 218Combined sources24
Helixi225 – 234Combined sources10
Beta strandi235 – 238Combined sources4
Helixi241 – 255Combined sources15
Helixi257 – 272Combined sources16
Helixi274 – 282Combined sources9
Helixi284 – 286Combined sources3
Helixi287 – 297Combined sources11
Beta strandi300 – 311Combined sources12
Beta strandi313 – 315Combined sources3
Beta strandi318 – 320Combined sources3
Beta strandi325 – 329Combined sources5
Helixi330 – 333Combined sources4
Turni337 – 339Combined sources3
Beta strandi340 – 342Combined sources3
Helixi361 – 363Combined sources3
Helixi368 – 385Combined sources18
Beta strandi401 – 403Combined sources3
Beta strandi406 – 408Combined sources3
Beta strandi410 – 414Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PKFX-ray2.10A1-419[»]
1Q5DX-ray1.93A1-419[»]
1Q5EX-ray2.65A1-419[»]
ProteinModelPortaliQ9KIZ4.
SMRiQ9KIZ4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KIZ4.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotationCurated

Phylogenomic databases

KOiK16400.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KIZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQEQANQSE TKPAFDFKPF APGYAEDPFP AIERLREATP IFYWDEGRSW
60 70 80 90 100
VLTRYHDVSA VFRDERFAVS REEWESSAEY SSAIPELSDM KKYGLFGLPP
110 120 130 140 150
EDHARVRKLV NPSFTSRAID LLRAEIQRTV DQLLDARSGQ EEFDVVRDYA
160 170 180 190 200
EGIPMRAISA LLKVPAECDE KFRRFGSATA RALGVGLVPR VDEETKTLVA
210 220 230 240 250
SVTEGLALLH GVLDERRRNP LENDVLTMLL QAEADGSRLS TKELVALVGA
260 270 280 290 300
IIAAGTDTTI YLIAFAVLNL LRSPEALELV KAEPGLMRNA LDEVLRFDNI
310 320 330 340 350
LRIGTVRFAR QDLEYCGASI KKGEMVFLLI PSALRDGTVF SRPDVFDVRR
360 370 380 390 400
DTSASLAYGR GPHVCPGVSL ARLEAEIAVG TIFRRFPEMK LKETPVFGYH
410
PAFRNIESLN VILKPSKAG
Length:419
Mass (Da):46,750
Last modified:October 1, 2000 - v1
Checksum:iFCCE0A193563688F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190R → Q in AAF26924 (PubMed:10662695).Curated1
Sequence conflicti211G → D in AAF26924 (PubMed:10662695).Curated1
Sequence conflicti353S → G in AAF26924 (PubMed:10662695).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210843 Genomic DNA. Translation: AAF26924.1.
AF217189 Genomic DNA. Translation: AAF62886.1.

Genome annotation databases

KEGGiag:AAF62886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF210843 Genomic DNA. Translation: AAF26924.1.
AF217189 Genomic DNA. Translation: AAF62886.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PKFX-ray2.10A1-419[»]
1Q5DX-ray1.93A1-419[»]
1Q5EX-ray2.65A1-419[»]
ProteinModelPortaliQ9KIZ4.
SMRiQ9KIZ4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGiag:AAF62886.

Phylogenomic databases

KOiK16400.

Enzyme and pathway databases

UniPathwayiUPA00774.

Miscellaneous databases

EvolutionaryTraceiQ9KIZ4.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC167_SORCE
AccessioniPrimary (citable) accession number: Q9KIZ4
Secondary accession number(s): Q9L8C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.