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Q9KI19

- RPOS_COXBU

UniProt

Q9KI19 - RPOS_COXBU

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Protein

RNA polymerase sigma factor RpoS

Gene

rpoS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi311 – 33020H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-HAMAP
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. sigma factor activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to stress Source: UniProtKB-HAMAP
  2. transcription initiation from bacterial-type RNA polymerase promoter Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Sigma factor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-1641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor RpoSUniRule annotation
Alternative name(s):
Sigma SUniRule annotation
Sigma-38UniRule annotation
Gene namesi
Name:rpoSUniRule annotation
Ordered Locus Names:CBU_1669
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352RNA polymerase sigma factor RpoSPRO_0000318558Add
BLAST

Proteomic databases

PRIDEiQ9KI19.

Expressioni

Developmental stagei

Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

Interactioni

Subunit structurei

Interacts with the RNA polymerase core enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1669.

Structurei

3D structure databases

ProteinModelPortaliQ9KI19.
SMRiQ9KI19. Positions 102-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 11234Sigma-70 factor domain-1UniRule annotationAdd
BLAST
Regioni117 – 18771Sigma-70 factor domain-2UniRule annotationAdd
BLAST
Regioni197 – 27276Sigma-70 factor domain-3UniRule annotationAdd
BLAST
Regioni285 – 33854Sigma-70 factor domain-4UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi141 – 1444Interaction with polymerase core subunit RpoC

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0568.
HOGENOMiHOG000270273.
KOiK03087.
OMAiNILSPHE.
OrthoDBiEOG6XHC70.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
HAMAPiMF_00959. Sigma70_RpoS.
InterProiIPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012761. RNA_pol_sigma_RpoS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view]
PRINTSiPR00046. SIGMA70FCT.
SUPFAMiSSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsiTIGR02394. rpoS_proteo. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEiPS00715. SIGMA70_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KI19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTKTTKKTI KKAAKKIKKP SKRKIKKTAK KSRPKKPIKA SDHGLIFAKT
60 70 80 90 100
KKETTEKEDA ELANAKAKTK KRRETRSSDP TQIYLRELGF QPLLNAKEEL
110 120 130 140 150
KIARRVHKGD PKARKQMIEA NLRLVVKIAR HYVNRGLPFL DLIEEGNLGL
160 170 180 190 200
LTAVEKFDPE RGFRFSTYAT WWIRQTIERA IMNQSRTVRL PIHVIKELNV
210 220 230 240 250
YLRTAKKLTQ EVDHEATPED VAHLIDKPVQ EIRRIMDLAP SATSIDVPIS
260 270 280 290 300
EDGQKSLVDT LADDNNIDPA RLIQNVDLQD HIERWLAQLD ERHREVVILR
310 320 330 340 350
FGLHENEKGT LEAVGKAVGL TRERVRQIQI DALQQLRHIL EMEGVTGEEV

ED
Length:352
Mass (Da):40,471
Last modified:October 1, 2000 - v1
Checksum:i35EA31D1C1132251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244357 Genomic DNA. Translation: AAF61172.1.
AE016828 Genomic DNA. Translation: AAO91165.1.
RefSeqiNP_820651.1. NC_002971.3.
WP_010958362.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO91165; AAO91165; CBU_1669.
GeneIDi1209580.
KEGGicbu:CBU_1669.
PATRICi17932081. VBICoxBur82552_1659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244357 Genomic DNA. Translation: AAF61172.1 .
AE016828 Genomic DNA. Translation: AAO91165.1 .
RefSeqi NP_820651.1. NC_002971.3.
WP_010958362.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q9KI19.
SMRi Q9KI19. Positions 102-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_1669.

Proteomic databases

PRIDEi Q9KI19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO91165 ; AAO91165 ; CBU_1669 .
GeneIDi 1209580.
KEGGi cbu:CBU_1669.
PATRICi 17932081. VBICoxBur82552_1659.

Phylogenomic databases

eggNOGi COG0568.
HOGENOMi HOG000270273.
KOi K03087.
OMAi NILSPHE.
OrthoDBi EOG6XHC70.

Enzyme and pathway databases

BioCyci CBUR227377:GJ7S-1641-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
HAMAPi MF_00959. Sigma70_RpoS.
InterProi IPR014284. RNA_pol_sigma-70_dom.
IPR000943. RNA_pol_sigma70.
IPR009042. RNA_pol_sigma70_r1_2.
IPR007627. RNA_pol_sigma70_r2.
IPR007624. RNA_pol_sigma70_r3.
IPR007630. RNA_pol_sigma70_r4.
IPR013325. RNA_pol_sigma_r2.
IPR013324. RNA_pol_sigma_r3_r4.
IPR012761. RNA_pol_sigma_RpoS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00140. Sigma70_r1_2. 1 hit.
PF04542. Sigma70_r2. 1 hit.
PF04539. Sigma70_r3. 1 hit.
PF04545. Sigma70_r4. 1 hit.
[Graphical view ]
PRINTSi PR00046. SIGMA70FCT.
SUPFAMi SSF88659. SSF88659. 2 hits.
SSF88946. SSF88946. 1 hit.
TIGRFAMsi TIGR02394. rpoS_proteo. 1 hit.
TIGR02937. sigma70-ECF. 1 hit.
PROSITEi PS00715. SIGMA70_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a stress-induced alternate sigma factor, RpoS, of Coxiella burnetii and its expression during the development cycle."
    Seshadri R., Samuel J.E.
    Infect. Immun. 69:4874-4883(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
    Strain: RSA 493 / Nine Mile phase I.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiRPOS_COXBU
AccessioniPrimary (citable) accession number: Q9KI19
Secondary accession number(s): Q7C3E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3