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Q9KI19

- RPOS_COXBU

UniProt

Q9KI19 - RPOS_COXBU

Protein

RNA polymerase sigma factor RpoS

Gene

rpoS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi311 – 33020H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. sigma factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to stress Source: UniProtKB-HAMAP
    2. transcription initiation from bacterial-type RNA polymerase promoter Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Sigma factor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-1641-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase sigma factor RpoSUniRule annotation
    Alternative name(s):
    Sigma SUniRule annotation
    Sigma-38UniRule annotation
    Gene namesi
    Name:rpoSUniRule annotation
    Ordered Locus Names:CBU_1669
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352RNA polymerase sigma factor RpoSPRO_0000318558Add
    BLAST

    Proteomic databases

    PRIDEiQ9KI19.

    Expressioni

    Developmental stagei

    Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

    Interactioni

    Subunit structurei

    Interacts with the RNA polymerase core enzyme.UniRule annotation

    Protein-protein interaction databases

    STRINGi227377.CBU_1669.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KI19.
    SMRiQ9KI19. Positions 102-184.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni79 – 11234Sigma-70 factor domain-1UniRule annotationAdd
    BLAST
    Regioni117 – 18771Sigma-70 factor domain-2UniRule annotationAdd
    BLAST
    Regioni197 – 27276Sigma-70 factor domain-3UniRule annotationAdd
    BLAST
    Regioni285 – 33854Sigma-70 factor domain-4UniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi141 – 1444Interaction with polymerase core subunit RpoC

    Sequence similaritiesi

    Belongs to the sigma-70 factor family. RpoS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0568.
    HOGENOMiHOG000270273.
    KOiK03087.
    OMAiNILSPHE.
    OrthoDBiEOG6XHC70.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    HAMAPiMF_00959. Sigma70_RpoS.
    InterProiIPR014284. RNA_pol_sigma-70_dom.
    IPR000943. RNA_pol_sigma70.
    IPR009042. RNA_pol_sigma70_r1_2.
    IPR007627. RNA_pol_sigma70_r2.
    IPR007624. RNA_pol_sigma70_r3.
    IPR007630. RNA_pol_sigma70_r4.
    IPR013325. RNA_pol_sigma_r2.
    IPR013324. RNA_pol_sigma_r3_r4.
    IPR012761. RNA_pol_sigma_RpoS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00140. Sigma70_r1_2. 1 hit.
    PF04542. Sigma70_r2. 1 hit.
    PF04539. Sigma70_r3. 1 hit.
    PF04545. Sigma70_r4. 1 hit.
    [Graphical view]
    PRINTSiPR00046. SIGMA70FCT.
    SUPFAMiSSF88659. SSF88659. 2 hits.
    SSF88946. SSF88946. 1 hit.
    TIGRFAMsiTIGR02394. rpoS_proteo. 1 hit.
    TIGR02937. sigma70-ECF. 1 hit.
    PROSITEiPS00715. SIGMA70_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KI19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTKTTKKTI KKAAKKIKKP SKRKIKKTAK KSRPKKPIKA SDHGLIFAKT    50
    KKETTEKEDA ELANAKAKTK KRRETRSSDP TQIYLRELGF QPLLNAKEEL 100
    KIARRVHKGD PKARKQMIEA NLRLVVKIAR HYVNRGLPFL DLIEEGNLGL 150
    LTAVEKFDPE RGFRFSTYAT WWIRQTIERA IMNQSRTVRL PIHVIKELNV 200
    YLRTAKKLTQ EVDHEATPED VAHLIDKPVQ EIRRIMDLAP SATSIDVPIS 250
    EDGQKSLVDT LADDNNIDPA RLIQNVDLQD HIERWLAQLD ERHREVVILR 300
    FGLHENEKGT LEAVGKAVGL TRERVRQIQI DALQQLRHIL EMEGVTGEEV 350
    ED 352
    Length:352
    Mass (Da):40,471
    Last modified:October 1, 2000 - v1
    Checksum:i35EA31D1C1132251
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244357 Genomic DNA. Translation: AAF61172.1.
    AE016828 Genomic DNA. Translation: AAO91165.1.
    RefSeqiNP_820651.1. NC_002971.3.
    WP_010958362.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO91165; AAO91165; CBU_1669.
    GeneIDi1209580.
    KEGGicbu:CBU_1669.
    PATRICi17932081. VBICoxBur82552_1659.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF244357 Genomic DNA. Translation: AAF61172.1 .
    AE016828 Genomic DNA. Translation: AAO91165.1 .
    RefSeqi NP_820651.1. NC_002971.3.
    WP_010958362.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q9KI19.
    SMRi Q9KI19. Positions 102-184.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_1669.

    Proteomic databases

    PRIDEi Q9KI19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO91165 ; AAO91165 ; CBU_1669 .
    GeneIDi 1209580.
    KEGGi cbu:CBU_1669.
    PATRICi 17932081. VBICoxBur82552_1659.

    Phylogenomic databases

    eggNOGi COG0568.
    HOGENOMi HOG000270273.
    KOi K03087.
    OMAi NILSPHE.
    OrthoDBi EOG6XHC70.

    Enzyme and pathway databases

    BioCyci CBUR227377:GJ7S-1641-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    HAMAPi MF_00959. Sigma70_RpoS.
    InterProi IPR014284. RNA_pol_sigma-70_dom.
    IPR000943. RNA_pol_sigma70.
    IPR009042. RNA_pol_sigma70_r1_2.
    IPR007627. RNA_pol_sigma70_r2.
    IPR007624. RNA_pol_sigma70_r3.
    IPR007630. RNA_pol_sigma70_r4.
    IPR013325. RNA_pol_sigma_r2.
    IPR013324. RNA_pol_sigma_r3_r4.
    IPR012761. RNA_pol_sigma_RpoS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00140. Sigma70_r1_2. 1 hit.
    PF04542. Sigma70_r2. 1 hit.
    PF04539. Sigma70_r3. 1 hit.
    PF04545. Sigma70_r4. 1 hit.
    [Graphical view ]
    PRINTSi PR00046. SIGMA70FCT.
    SUPFAMi SSF88659. SSF88659. 2 hits.
    SSF88946. SSF88946. 1 hit.
    TIGRFAMsi TIGR02394. rpoS_proteo. 1 hit.
    TIGR02937. sigma70-ECF. 1 hit.
    PROSITEi PS00715. SIGMA70_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a stress-induced alternate sigma factor, RpoS, of Coxiella burnetii and its expression during the development cycle."
      Seshadri R., Samuel J.E.
      Infect. Immun. 69:4874-4883(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
      Strain: RSA 493 / Nine Mile phase I.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiRPOS_COXBU
    AccessioniPrimary (citable) accession number: Q9KI19
    Secondary accession number(s): Q7C3E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3