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Protein

RNA polymerase sigma factor RpoS

Gene

rpoS

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi311 – 330H-T-H motifUniRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Sigma factor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1639-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase sigma factor RpoSUniRule annotation
Alternative name(s):
Sigma SUniRule annotation
Sigma-38UniRule annotation
Gene namesi
Name:rpoSUniRule annotation
Ordered Locus Names:CBU_1669
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185581 – 352RNA polymerase sigma factor RpoSAdd BLAST352

Proteomic databases

PRIDEiQ9KI19

Expressioni

Developmental stagei

Found in the large cell variant (LCV) stage, very little is present in the small cell variant (SCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

Interactioni

Subunit structurei

Interacts with the RNA polymerase core enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1669

Structurei

3D structure databases

ProteinModelPortaliQ9KI19
SMRiQ9KI19
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 112Sigma-70 factor domain-1UniRule annotationAdd BLAST34
Regioni117 – 187Sigma-70 factor domain-2UniRule annotationAdd BLAST71
Regioni197 – 272Sigma-70 factor domain-3UniRule annotationAdd BLAST76
Regioni285 – 338Sigma-70 factor domain-4UniRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi141 – 144Interaction with polymerase core subunit RpoC4

Sequence similaritiesi

Belongs to the sigma-70 factor family. RpoS subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DG1 Bacteria
COG0568 LUCA
HOGENOMiHOG000270273
KOiK03087
OMAiITNRESQ

Family and domain databases

Gene3Di1.10.10.10, 2 hits
HAMAPiMF_00959 Sigma70_RpoS, 1 hit
InterProiView protein in InterPro
IPR014284 RNA_pol_sigma-70_dom
IPR000943 RNA_pol_sigma70
IPR009042 RNA_pol_sigma70_r1_2
IPR007627 RNA_pol_sigma70_r2
IPR007624 RNA_pol_sigma70_r3
IPR007630 RNA_pol_sigma70_r4
IPR013325 RNA_pol_sigma_r2
IPR013324 RNA_pol_sigma_r3/r4-like
IPR012761 RNA_pol_sigma_RpoS
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00140 Sigma70_r1_2, 1 hit
PF04542 Sigma70_r2, 1 hit
PF04539 Sigma70_r3, 1 hit
PF04545 Sigma70_r4, 1 hit
PRINTSiPR00046 SIGMA70FCT
SUPFAMiSSF88659 SSF88659, 2 hits
SSF88946 SSF88946, 1 hit
TIGRFAMsiTIGR02394 rpoS_proteo, 1 hit
TIGR02937 sigma70-ECF, 1 hit
PROSITEiView protein in PROSITE
PS00715 SIGMA70_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KI19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKTTKKTI KKAAKKIKKP SKRKIKKTAK KSRPKKPIKA SDHGLIFAKT
60 70 80 90 100
KKETTEKEDA ELANAKAKTK KRRETRSSDP TQIYLRELGF QPLLNAKEEL
110 120 130 140 150
KIARRVHKGD PKARKQMIEA NLRLVVKIAR HYVNRGLPFL DLIEEGNLGL
160 170 180 190 200
LTAVEKFDPE RGFRFSTYAT WWIRQTIERA IMNQSRTVRL PIHVIKELNV
210 220 230 240 250
YLRTAKKLTQ EVDHEATPED VAHLIDKPVQ EIRRIMDLAP SATSIDVPIS
260 270 280 290 300
EDGQKSLVDT LADDNNIDPA RLIQNVDLQD HIERWLAQLD ERHREVVILR
310 320 330 340 350
FGLHENEKGT LEAVGKAVGL TRERVRQIQI DALQQLRHIL EMEGVTGEEV

ED
Length:352
Mass (Da):40,471
Last modified:October 1, 2000 - v1
Checksum:i35EA31D1C1132251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244357 Genomic DNA Translation: AAF61172.1
AE016828 Genomic DNA Translation: AAO91165.1
RefSeqiNP_820651.1, NC_002971.3
WP_010958362.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO91165; AAO91165; CBU_1669
GeneIDi1209580
KEGGicbu:CBU_1669
PATRICifig|227377.7.peg.1659

Similar proteinsi

Entry informationi

Entry nameiRPOS_COXBU
AccessioniPrimary (citable) accession number: Q9KI19
Secondary accession number(s): Q7C3E6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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