Q9KGL9 (KTHY_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Gene names

Name:	tmk
Ordered Locus Names:	BH0042

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Thymidylate kinase HAMAP MF_00165		PRO_0000155235
Regions
	Nucleotide binding	11 – 18	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9KGL9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8F2E406148850D34	FASTA	210	23,651
	10 20 30 40 50 60 MTKGCFITVE GGEGAGKTSA LDAIEEMLRE NGLSVVRTRE PGGIPIAEQI RSIILDVDHT 70 80 90 100 110 120 RMDPRTEALL YAAARRQHLV EKVLPALEAG HVVLCDRFID SSLAYQGYAR GIGFEDILAI 130 140 150 160 170 180 NEFAIEGRYP DLTLLFRVDP DVGLSRIHRD QSREQNRLDQ EALTFHQKVK EGYERIVETY 190 200 210 PERVVEIDAN QSFDQVVADA VRMIKQRLSL

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB03761.1.
PIR	B83655.
RefSeq	NP_240908.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9KGL9.
SMR	Q9KGL9. Positions 4-208.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000052299; EBBACP00000050938; EBBACG00000052290.
GeneID	891680.
GenomeReviews	Gene locus BH0042 in contig BA000004_GR.
KEGG	bha:BH0042.
NMPDR	fig|272558.1.peg.42.
PATRIC	18936910. VBIBacHal18977_0045.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002345.
HOGENOM	HBG626009.
OMA	RFITFEG.
PhylomeDB	Q9KGL9.
ProtClustDB	CLSK2748791.
Enzyme and pathway databases
BioCyc	BHAL272558:BH0042-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_BACHD

Accession

Primary (citable) accession number: Q9KGL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program