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Q9KGJ5 (KPRS_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Ordered Locus Names:BH0066
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
PRO_0000141109

Regions

Region216 – 22914Binding of phosphoribosylpyrophosphate Potential

Sites

Metal binding1331Magnesium Potential
Metal binding1351Magnesium Potential
Metal binding1441Magnesium Potential
Metal binding1481Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q9KGJ5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C4B7D7FACF3C94B8

FASTA31634,521
        10         20         30         40         50         60 
MANYGDPNLK VFTLNSNKGL AYEITERIGV PMGKSSVTRF SDGEVQINIE ESIRGCDVFL 

        70         80         90        100        110        120 
IQSTAAPANE HIMELLIMID AVKRASAKTI NVVIPYYGYA RQDRKARARE PITAKLVANL 

       130        140        150        160        170        180 
LETAGATRVL TLDLHATQIQ GFFDIPVDQL MGVPILAEFF EKKGLDDVVV VSPDHGGVVR 

       190        200        210        220        230        240 
ARKLADRLKA PIAIIDKRRP KPNVAEVMNI VGHIEGKTAI IIDDIIDTAG TITLAANALV 

       250        260        270        280        290        300 
EHGAKEVYAC CTHPVLSGPA IERIKNSKIK ELVVMNTIEL EEEKLIDKIT TLSVAPLMAE 

       310 
AIVRVHEHSS VSLLFD

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB03785.1.
PIRB83658.
RefSeqNP_240932.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9KGJ5.
SMRQ9KGJ5. Positions 4-315.
ModBaseSearch...

Protein-protein interaction databases

STRING272558.BH0066.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB03785; BAB03785; BAB03785.
GeneID892693.
KEGGbha:BH0066.
PATRIC18936962. VBIBacHal18977_0071.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0462.
KOK00948.
OMAYVQIQES.
ProtClustDBPRK01259.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-73-MONOMER.
UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_BACHD
AccessionPrimary (citable) accession number: Q9KGJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 1, 2000
Last modified: May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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