Reviewed, UniProtKB/Swiss-Prot Q9KGJ3 (PTH_BACHD)

Names and origin

Protein names

Recommended name:
    Peptidyl-tRNA hydrolase
      Short name=PTH
    EC=3.1.1.29

Gene names

Name:	pth
Synonyms:	spoVC
Ordered Locus Names:	BH0068

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis By similarity.
Catalytic activity	N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. HAMAP MF_00083
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the PTH family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminoacyl-tRNA hydrolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 185	185	Peptidyl-tRNA hydrolase HAMAP MF_00083		PRO_0000187688

Sequences

	Sequence		Length	Mass (Da)
	Q9KGJ3-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AAC87F8B5354269D	FASTA	185	20,548
	10 20 30 40 50 60 MKLIVGLGNP GAKYDGTRHN VGFDVVDAVA RRLNIEIKQS KANGLYGEGR IDGEKIFLLK 70 80 90 100 110 120 PQTFMNRSGE SVRPFLEYYN MEVEDLLVIY DDLDLPVGKI RLRQKGSAGG HNGMKSLIAH 130 140 150 160 170 180 LGTSDFKRIR VGVDRPAPGE TVVQHVLGRY RPEEKDAISE AIDLSAEAAE AFTKKPFLEV MNTFN

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB03787.1.
PIR	D83658.
RefSeq	NP_240934.1.
3D structure databases
HSSP	HSSP built from PDB template 2PTH based on UniProtKB P23932.
ModBase	Search...
Genome annotation databases
GeneID	892331.
GenomeReviews	Gene locus BH0068 in contig BA000004_GR.
KEGG	bha:BH0068.
NMPDR	fig|272558.1.peg.68.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KGJ3.
OMA	TEIDINN.
Enzyme and pathway databases
BioCyc	BHAL272558:BH0068-MON.
BRENDA	3.1.1.29. 191865.
Family and domain databases
HAMAP	MF_00083. [Tree]
InterPro	IPR001328. Pept_tRNA_hydro. IPR018171. Pept_tRNA_hydro_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.1470. Pept_tRNA_hydro. 1 hit.
PANTHER	PTHR17224. Pept_tRNA_hydro. 1 hit.
Pfam	PF01195. Pept_tRNA_hydro. 1 hit. [Graphical view]
ProDom	PD005324. PeptRNAhydrolase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00447. pth. 1 hit.
PROSITE	PS01195. PEPT_TRNA_HYDROL_1. 1 hit. PS01196. PEPT_TRNA_HYDROL_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTH_BACHD

Accession

Primary (citable) accession number: Q9KGJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)