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Protein

dCTP deaminase

Gene

dcd

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. dCTP deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Alternative name(s):
Deoxycytidine triphosphate deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:BH0368
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559641 – 177dCTP deaminaseAdd BLAST177

Interactioni

Protein-protein interaction databases

STRINGi272558.BH0368.

Structurei

Secondary structure

1177
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 13Combined sources9
Beta strandi16 – 21Combined sources6
Helixi24 – 26Combined sources3
Beta strandi32 – 36Combined sources5
Beta strandi38 – 43Combined sources6
Turni45 – 47Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi53 – 55Combined sources3
Beta strandi59 – 63Combined sources5
Beta strandi66 – 71Combined sources6
Beta strandi76 – 86Combined sources11
Beta strandi91 – 97Combined sources7
Helixi99 – 102Combined sources4
Turni103 – 105Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi112 – 114Combined sources3
Beta strandi119 – 128Combined sources10
Beta strandi130 – 132Combined sources3
Beta strandi134 – 137Combined sources4
Beta strandi140 – 152Combined sources13
Turni160 – 163Combined sources4
Helixi172 – 174Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XJCX-ray2.35A/B/C/D/E/F1-177[»]
ProteinModelPortaliQ9KFV3.
SMRiQ9KFV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
KOiK01494.
OMAiNIPCIHP.
OrthoDBiPOG091H02A6.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KFV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSGKTISE KLTEKELEIT PLTEEQIQPA SVDLRLGPHF VTIDDSKEAV
60 70 80 90 100
ISFERPIRYR EWTTSDETIV LPPHTFLLAT TMETVKLPNH LTAFVEGRSS
110 120 130 140 150
VGRLGLFIQN AGWVDPGFNG QITLELFNAN RLPIELPIGR RICQLVFAEV
160 170
TGEVAPYQGK YLFQKGATMS EIYKDAF
Length:177
Mass (Da):19,897
Last modified:October 1, 2000 - v1
Checksum:iD15AE75387847E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB04087.1.
PIRiH83695.
RefSeqiWP_010896547.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB04087; BAB04087; BAB04087.
KEGGibha:BH0368.
PATRICi18937658. VBIBacHal18977_0388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB04087.1.
PIRiH83695.
RefSeqiWP_010896547.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XJCX-ray2.35A/B/C/D/E/F1-177[»]
ProteinModelPortaliQ9KFV3.
SMRiQ9KFV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH0368.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB04087; BAB04087; BAB04087.
KEGGibha:BH0368.
PATRICi18937658. VBIBacHal18977_0388.

Phylogenomic databases

eggNOGiENOG4105DHP. Bacteria.
COG0717. LUCA.
KOiK01494.
OMAiNIPCIHP.
OrthoDBiPOG091H02A6.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase. 1 hit.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCD_BACHD
AccessioniPrimary (citable) accession number: Q9KFV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.