Q9KFL5 (UPPP1_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase 1
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1

Gene names

Name:	uppP1
Synonyms:	bacA1, upk1
Ordered Locus Names:	BH0464

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151099
Regions
	Transmembrane	8 – 28	21	Helical; Potential
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	195 – 215	21	Helical; Potential
	Transmembrane	230 – 250	21	Helical; Potential
	Transmembrane	253 – 273	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9KFL5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2AE1578AF80AF883	FASTA	274	30,607
	10 20 30 40 50 60 MEWSQELWLL IKYLLLGLFQ GFTEPIPVSS SGHLVLLQHF LGIEIEGLSF EVMVNFASLF 70 80 90 100 110 120 AVIAIYRFDL LKLVKGSARY VLYQDAQGKG DFRISFYLLL ATVPAVLAAL LFKDWIETEL 130 140 150 160 170 180 KQLHVIAFAL LITGMALWLI RHLNGRKQDG DITLKDALLV GLAQTAALIP GISRSGATIV 190 200 210 220 230 240 AAMGLGWRQE TALRFSFFLY IPISLGSGVL AISDIVQDPH FTALWIPYTI AFIGSFIASY 250 260 270 VSLLWFMNIM RHGKLIYFAL YCWLAGLIVL SLLS

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB04183.1.
PIR	H83707.
RefSeq	NP_241330.1. NC_002570.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000050199; EBBACP00000048838; EBBACG00000050190.
GeneID	891613.
GenomeReviews	Gene locus BH0464 in contig BA000004_GR.
KEGG	bha:BH0464.
NMPDR	fig|272558.1.peg.464.
PATRIC	18937858. VBIBacHal18977_0488.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002490.
HOGENOM	HBG391969.
OMA	MEWFEAL.
PhylomeDB	Q9KFL5.
ProtClustDB	PRK12554.
Enzyme and pathway databases
BioCyc	BHAL272558:BH0464-MONOMER.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_BACHD

Accession

Primary (citable) accession number: Q9KFL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program