Reviewed, UniProtKB/Swiss-Prot Q9KFI7 (UXAB_BACHD)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	BH0492

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	512 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 512	512	Altronate oxidoreductase HAMAP MF_00670		PRO_0000170738
Regions
	Nucleotide binding	26 – 37	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9KFI7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D27D7862C2913A05	FASTA	512	58,450
	10 20 30 40 50 60 MEKLSHGLVT SRNMIRYKSS QLPERVLQFG EGNFLRGFID WMIQQMNKQN VFNGRVVAIQ 70 80 90 100 110 120 PTPHGKVVPK LQEQDSLYTV WLRGIADGET VDHHEVITSI SRGLNPYTNW QDVLEVAASP 130 140 150 160 170 180 DISVVFSNTT EAGLTYLEEG YDKEKAPLSF PGKLAACLWH RYETLGWGEG SGLVIIPCEL 190 200 210 220 230 240 VEQNGKVLKE LVCRYAKAWN FPQEFFTWLE RENEFCHTLV DRIVPGFPSD TADECFERLG 250 260 270 280 290 300 YEDILLTVAE PYHLFIIEGS ERVRKLLPFN EAGLHVRWNH LEKHRNMKVR VLNGTHTFMF 310 320 330 340 350 360 ALSYLSGVDT VGEAMADEQL CSFIRKGLFE EIIPCVDAPE QEVTAFAETV LERFENPFLQ 370 380 390 400 410 420 HRLTDIGLNA VNKFRTRLMP TFNDYVAQTG EAPTYLLFSL AALINYYRGV EEDGPFLIGR 430 440 450 460 470 480 RREDSYLIRD DLEVIEAFKV GWQQVNTGKL SLAQLCEDLL SKRELWGVDL SMERKVVDKV 490 500 510 AESLQIIVEK GMRQAISGVL NQIGGNNHVH KQ

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB04211.1.
PIR	D83711.
RefSeq	NP_241358.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	892054.
GenomeReviews	Gene locus BH0492 in contig BA000004_GR.
KEGG	bha:BH0492.
NMPDR	fig|272558.1.peg.492.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KFI7.
OMA	Q9KFI7. LTVAEPY.
Enzyme and pathway databases
BioCyc	BHAL272558:BH0492-MON.
BRENDA	1.1.1.58. 191865.
Family and domain databases
HAMAP	MF_00670. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAB_BACHD

Accession

Primary (citable) accession number: Q9KFI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)