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Q9KFH7 (RIR2_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase subunit beta

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:nrdB
Ordered Locus Names:BH0502
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Tetramer of two alpha and two beta subunits By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Ribonucleoside-diphosphate reductase subunit beta
PRO_0000190468

Sites

Active site1251 By similarity
Metal binding881Iron 1 By similarity
Metal binding1181Iron 1 By similarity
Metal binding1181Iron 2 By similarity
Metal binding1211Iron 1 By similarity
Metal binding1851Iron 2 By similarity
Metal binding2191Iron 2 By similarity
Metal binding2221Iron 2 By similarity

Secondary structure

.................................. 345
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KFH7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D89208F7518152BC

FASTA34540,242
        10         20         30         40         50         60 
MEQLQKRKIY DTTASNASTG ILNGKSSNVL NWDDVRFSWA YPLYKNMLAN FWTPFEINMS 

        70         80         90        100        110        120 
HDAKQFPTLT ETEQEAFKKI IGLLAFLDSV QTDYSMRAAE YLTDSSLAAL MSVLSFQEVV 

       130        140        150        160        170        180 
HNQSYSYVLS SLVPKATQDE IFEYWKHDDV LKERNEFIID GYEKFVDNPT PKTFLESIVY 

       190        200        210        220        230        240 
DVILEGLNFY SGFAFFYNLA RNQKMVSTST MINYINRDEQ LHVYLFTNIF KELLVEFPEL 

       250        260        270        280        290        300 
NTEETKTFVK TTLMKAADLE KDWFRYIIGD KIPGINPEDM ETYISFIANK RAVQLGMEKP 

       310        320        330        340 
YPEIKHNPMK WIRAYEDVNS GKSDFFEQKS RQYAKVSADN GFDEL 

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000004 Genomic DNA. Translation: BAB04221.1.
PIRF83712.
RefSeqNP_241368.1. NC_002570.2.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2RCCX-ray1.90A/B/C1-345[»]
ProteinModelPortalQ9KFH7.
SMRQ9KFH7. Positions 1-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272558.BH0502.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB04221; BAB04221; BAB04221.
GeneID893380.
KEGGbha:BH0502.
PATRIC18937944. VBIBacHal18977_0531.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0208.
KOK00526.
OMASEIFNAY.
OrthoDBEOG6J48J7.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-539-MONOMER.
UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR026023. RNR_bsu_prok.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
PIRSFPIRSF000355. NrdB. 1 hit.
SUPFAMSSF47240. SSF47240. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9KFH7.

Entry information

Entry nameRIR2_BACHD
AccessionPrimary (citable) accession number: Q9KFH7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways