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Protein

Serine-protein kinase RsbW

Gene

rsbW

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B).UniRule annotation

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-580-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Serine-protein kinase RsbWUniRule annotation (EC:2.7.11.1UniRule annotation)
Alternative name(s):
Anti-sigma-B factorUniRule annotation
Sigma-B negative effector RsbWUniRule annotation
Gene namesi
Name:rsbWUniRule annotation
Ordered Locus Names:BH0528
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002035291 – 162Serine-protein kinase RsbWAdd BLAST162

Proteomic databases

PRIDEiQ9KFF1

Interactioni

Protein-protein interaction databases

STRINGi272558.BH0528

Structurei

3D structure databases

ProteinModelPortaliQ9KFF1
SMRiQ9KFF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anti-sigma-factor family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBE Bacteria
COG2172 LUCA
HOGENOMiHOG000269932
KOiK04757
OMAiKMGFSYE
OrthoDBiPOG091H0FML

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.565.10, 1 hit
HAMAPiMF_00638 Anti_sigma_B, 1 hit
InterProiView protein in InterPro
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR010193 RsbW
PfamiView protein in Pfam
PF13581 HATPase_c_2, 1 hit
SUPFAMiSSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR01924 rsbW_low_gc, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KFF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVHQPETIE MTVPAKSEFV GVVRLTVSGI ANRLGYTYDD IEDIKIAVAE
60 70 80 90 100
ACTNVVDHAY DEGGTMGLSF HLYEDRMEII VTDQGQSFDM DAFRESLGPI
110 120 130 140 150
DGSKPIQDLK EGGLGLFLIN TLMDKVEMKE DSGVVLAMTK FLQRDEVDNR
160
VDGISATQTE QR
Length:162
Mass (Da):17,992
Last modified:October 1, 2000 - v1
Checksum:i75ED56364C715554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB04247.1
PIRiH83715
RefSeqiWP_010896706.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB04247; BAB04247; BAB04247
KEGGibha:BH0528

Similar proteinsi

Entry informationi

Entry nameiRSBW_BACHD
AccessioniPrimary (citable) accession number: Q9KFF1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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