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Reviewed, UniProtKB/Swiss-Prot Q9KET5 (FABH2_BACHD)

Last modified February 9, 2010. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2
    EC=2.3.1.180
Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase III protein 2
    Beta-ketoacyl-ACP synthase III 2
      Short name=KAS III 2
Gene names
Name: fabH2
Ordered Locus Names: BH0764
OrganismBacillus halodurans [Complete proteome] [HAMAP]
Taxonomic identifier86665 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/acpP and fabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the fabH family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3323323-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 HAMAP MF_01815
PRO_0000110398

Regions

Region253 – 2575ACP-binding By similarity

Sites

Active site1151 By similarity
Active site2521 By similarity
Active site2821 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9KET5-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D0D70C10F8B69C6D

FASTA33236,264
        10         20         30         40         50         60 
MNVSKARITA IGSYVPERRL TNDDLEKMVD TNDEWIVKRT GIRERRIAAD DEFTSDIGYK 

        70         80         90        100        110        120 
AVQDLIARYE KSVDDVDMII VCTFTPDFKT PSAASLIQAK LGIQNTGAID LNAACAGFTY 

       130        140        150        160        170        180 
GLHMANGLIS SGLHRKILVI GAETISKVTD YTDRTTCILF GDGAGAVLVE YDENEPSFVS 

       190        200        210        220        230        240 
FNLGSEGERA NKLYCTGLAE QMNGEELVNT GNLVQSGREV YKWAVNTVPA GMKAVLEKAA 

       250        260        270        280        290        300 
MKRNEIDWFV PHSANLRMIE SICDKSGIPL EQTLYSLVQY GNTSSATIPL ALDIGVREGK 

       310        320        330 
LKHGDNVLLY GFGGGLAHAG LILRWTVPTE KN

« Hide

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References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB04483.1.
PIRD83745.
RefSeqNP_241630.1.

3D structure databases

SMRQ9KET5. Positions 6-326.
ModBaseSearch...

Genome annotation databases

GeneID892873.
GenomeReviewsGene locus BH0764 in contig BA000004_GR.
KEGGbha:BH0764.
NMPDRfig|272558.1.peg.764.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMAIESICEK.
PhylomeDBQ9KET5.

Enzyme and pathway databases

BioCycBHAL272558:BH0764-MONOMER.
BRENDA2.3.1.180. 191865.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
[Graphical view]
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00747. fabH. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameFABH2_BACHD
AccessionPrimary (citable) accession number: Q9KET5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: October 1, 2000
Last modified: February 9, 2010
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents