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Protein

Membrane protein insertase YidC 2

Gene

yidC2

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Protein family/group databases

TCDBi2.A.9.3.6. the membrane protein insertase (yidc/alb3/oxa1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidC 2UniRule annotation
Alternative name(s):
Foldase YidC 2UniRule annotation
Membrane integrase YidC 2UniRule annotation
Membrane protein YidC 2UniRule annotation
Gene namesi
Name:yidC2UniRule annotation
Ordered Locus Names:BH1169
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalUniRule annotationAdd BLAST21
Transmembranei133 – 153HelicalUniRule annotationAdd BLAST21
Transmembranei163 – 183HelicalUniRule annotationAdd BLAST21
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21
Transmembranei248 – 268HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22UniRule annotationAdd BLAST22
ChainiPRO_000002037623 – 280Membrane protein insertase YidC 2Add BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi23N-palmitoyl cysteineUniRule annotation1
Lipidationi23S-diacylglycerol cysteineUniRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1169.

Structurei

Secondary structure

1280
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 40Combined sources12
Helixi42 – 55Combined sources14
Helixi60 – 103Combined sources44
Helixi111 – 128Combined sources18
Helixi132 – 135Combined sources4
Helixi138 – 155Combined sources18
Turni157 – 161Combined sources5
Helixi176 – 193Combined sources18
Helixi216 – 222Combined sources7
Helixi224 – 235Combined sources12
Helixi238 – 255Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO6X-ray2.40A27-266[»]
3WO7X-ray3.20A/B27-267[»]
SMRiQ9KDP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000009662.
KOiK03217.
OMAiLIMNEIQ.
OrthoDBiPOG091H00BE.

Family and domain databases

HAMAPiMF_01811. YidC_type2. 1 hit.
InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
IPR023060. YidC/YidC1/YidC2_Firmicutes.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KDP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYMKRRLLL FAGILLLVAL AGCSTTDPIT SESEGIWNHF FVYPMSWLIT
60 70 80 90 100
TVANLLNGSY GLSIIIVTIL IRLALLPLTL KQQKSMRAMQ VIRPEMEAIQ
110 120 130 140 150
KKYKEKGSKD PKVQQEMQKE LLGLYQKHGV NPMAGCLPLF IQLPILMAFY
160 170 180 190 200
FAIMRTEEIR YHTFLWFDLG QPDYILPFVA GITTYFQFKM TMSHQQQMQK
210 220 230 240 250
TNPSDSDNPM ANMMQMQMKV MLYVMPVMII IAGLSLPSAL SLYWVIGNIF
260 270 280
MIIQTYFIVV KAPPLEVEQT KQKSSKPNKA
Length:280
Mass (Da):32,108
Last modified:October 1, 2000 - v1
Checksum:i724F78BC47E7C270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB04888.1.
PIRiA83796.

Genome annotation databases

EnsemblBacteriaiBAB04888; BAB04888; BAB04888.
KEGGibha:BH1169.
PATRICi18939396. VBIBacHal18977_1216.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB04888.1.
PIRiA83796.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WO6X-ray2.40A27-266[»]
3WO7X-ray3.20A/B27-267[»]
SMRiQ9KDP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH1169.

Protein family/group databases

TCDBi2.A.9.3.6. the membrane protein insertase (yidc/alb3/oxa1) family.

Protocols and materials databases

DNASUi892166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB04888; BAB04888; BAB04888.
KEGGibha:BH1169.
PATRICi18939396. VBIBacHal18977_1216.

Phylogenomic databases

eggNOGiENOG4105DHW. Bacteria.
COG0706. LUCA.
HOGENOMiHOG000009662.
KOiK03217.
OMAiLIMNEIQ.
OrthoDBiPOG091H00BE.

Family and domain databases

HAMAPiMF_01811. YidC_type2. 1 hit.
InterProiIPR028055. Membr_insert_YidC/Oxa1_C.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
IPR023060. YidC/YidC1/YidC2_Firmicutes.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03592. yidC_oxa1_cterm. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIDC2_BACHD
AccessioniPrimary (citable) accession number: Q9KDP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.