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Protein

Ferrochelatase

Gene

hemH

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ferrous insertion into protoporphyrin IX.By similarity

Catalytic activityi

Protoheme + 2 H+ = protoporphyrin + Fe2+.

Pathwayi: protoheme biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.
Proteins known to be involved in this subpathway in this organism are:
  1. Ferrochelatase (hemH)
This subpathway is part of the pathway protoheme biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi181IronBy similarity1
Metal bindingi262IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processHeme biosynthesis, Porphyrin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferrochelatase (EC:4.99.1.1)
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene namesi
Name:hemH
Ordered Locus Names:BH1203
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001751101 – 310FerrochelataseAdd BLAST310

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1203.

Structurei

3D structure databases

ProteinModelPortaliQ9KDK9.
SMRiQ9KDK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferrochelatase family.Curated

Phylogenomic databases

eggNOGiENOG4107TTW. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060729.
KOiK01772.
OMAiMHKDGIT.
OrthoDBiPOG091H041Q.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiView protein in InterPro
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiView protein in Pfam
PF00762. Ferrochelatase. 1 hit.
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiView protein in PROSITE
PS00534. FERROCHELATASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KDK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKKKIGLLV MAYGTPRTKE EIEPYYTHIR HGRKPSQELL DDLTERYEAI
60 70 80 90 100
GGVSPLAKIT DDQAIALEQK LNELYDDIEF KSYLGLKHID PFIEDAVEQM
110 120 130 140 150
KEDGVQEAVS IVLAPHFSTF SVKSYNGRAH EESKKIGGPR IQSVESWYDE
160 170 180 190 200
PLFIQYWVDQ VNDTMAKIED KDKACVIFSA HSLPEKIVDY GDPYPQQLKE
210 220 230 240 250
TADLIAKGAG ITNYAVGWQS EGNTPEPWLG PDVQDLTRDL YETHGYTSMI
260 270 280 290 300
YCPVGFVADH LEVLYDNDYE CKVVTDELGI DYYRPEMPNA KPEFIDCLAT
310
VIQKKLAEKE
Length:310
Mass (Da):35,272
Last modified:October 1, 2000 - v1
Checksum:iAA28CE33BAB1FF21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB04922.1.
PIRiC83800.
RefSeqiWP_010897372.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB04922; BAB04922; BAB04922.
KEGGibha:BH1203.
PATRICi18939460. VBIBacHal18977_1248.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB04922.1.
PIRiC83800.
RefSeqiWP_010897372.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9KDK9.
SMRiQ9KDK9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH1203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB04922; BAB04922; BAB04922.
KEGGibha:BH1203.
PATRICi18939460. VBIBacHal18977_1248.

Phylogenomic databases

eggNOGiENOG4107TTW. Bacteria.
COG0276. LUCA.
HOGENOMiHOG000060729.
KOiK01772.
OMAiMHKDGIT.
OrthoDBiPOG091H041Q.

Enzyme and pathway databases

UniPathwayiUPA00252; UER00325.

Family and domain databases

CDDicd00419. Ferrochelatase_C. 1 hit.
cd03411. Ferrochelatase_N. 1 hit.
HAMAPiMF_00323. Ferrochelatase. 1 hit.
InterProiView protein in InterPro
IPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
IPR033644. Ferrochelatase_C.
IPR033659. Ferrochelatase_N.
PANTHERiPTHR11108. PTHR11108. 1 hit.
PfamiView protein in Pfam
PF00762. Ferrochelatase. 1 hit.
TIGRFAMsiTIGR00109. hemH. 1 hit.
PROSITEiView protein in PROSITE
PS00534. FERROCHELATASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHEMH_BACHD
AccessioniPrimary (citable) accession number: Q9KDK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: March 15, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.