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Q9KDK9 (HEMH_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ferrochelatase
EC=4.99.1.1
Alternative name(s):
Heme synthase
Protoheme ferro-lyase
Gene names
Name:hemH
Ordered Locus Names:BH1203
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323

Catalytic activity

Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323

Pathway

Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323

Subcellular location

Cytoplasm By similarity HAMAP MF_00323.

Sequence similarities

Belongs to the ferrochelatase family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processheme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionferrochelatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 310310Ferrochelatase HAMAP MF_00323
PRO_0000175110

Sites

Metal binding1811Iron By similarity
Metal binding2621Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KDK9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AA28CE33BAB1FF21

FASTA31035,272
        10         20         30         40         50         60 
MTKKKIGLLV MAYGTPRTKE EIEPYYTHIR HGRKPSQELL DDLTERYEAI GGVSPLAKIT 

        70         80         90        100        110        120 
DDQAIALEQK LNELYDDIEF KSYLGLKHID PFIEDAVEQM KEDGVQEAVS IVLAPHFSTF 

       130        140        150        160        170        180 
SVKSYNGRAH EESKKIGGPR IQSVESWYDE PLFIQYWVDQ VNDTMAKIED KDKACVIFSA 

       190        200        210        220        230        240 
HSLPEKIVDY GDPYPQQLKE TADLIAKGAG ITNYAVGWQS EGNTPEPWLG PDVQDLTRDL 

       250        260        270        280        290        300 
YETHGYTSMI YCPVGFVADH LEVLYDNDYE CKVVTDELGI DYYRPEMPNA KPEFIDCLAT 

       310 
VIQKKLAEKE

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB04922.1.
PIRC83800.
RefSeqNP_242069.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9KDK9.
SMRQ9KDK9. Positions 2-307.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000051194; EBBACP00000049833; EBBACG00000051185.
GeneID892240.
GenomeReviewsGene locus BH1203 in contig BA000004_GR.
KEGGbha:BH1203.
NMPDRfig|272558.1.peg.1203.
PATRIC18939460. VBIBacHal18977_1248.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000002085.
HOGENOMHBG697135.
OMALLQMGGP.
PhylomeDBQ9KDK9.
ProtClustDBPRK12435.

Enzyme and pathway databases

BioCycBHAL272558:BH1203-MONOMER.

Family and domain databases

HAMAPMF_00323. Ferrochelatase.
[Tree]
InterProIPR001015. Ferrochelatase.
IPR019772. Ferrochelatase_AS.
[Graphical view]
KOK01772.
PANTHERPTHR11108. Ferrochelatase. 1 hit.
PfamPF00762. Ferrochelatase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00109. HemH. 1 hit.
PROSITEPS00534. FERROCHELATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHEMH_BACHD
AccessionPrimary (citable) accession number: Q9KDK9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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