Reviewed, UniProtKB/Swiss-Prot Q9KD93 (AROE_BACHD)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Synonyms:	aroD
Ordered Locus Names:	BH1324

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 278	278	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000135991
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	66	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9KD93-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2000144C84686264	FASTA	278	30,630
	10 20 30 40 50 60 MKKLFGLLGH PVGHSLSPLM HNQMFQLLDF DGYYHAFDVE PSQLEKAVEG ARALQMQGFN 70 80 90 100 110 120 VTIPHKVTIM DYLDMVDEEA QEIGAVNTVV MKDGQLFGSN TDGQGYLESL MDVVTTPFPT 130 140 150 160 170 180 QDVLIIGAGG AARAIGTVLK REKVRSITIA NRTLAKAEEF SGVLESSETS CSALSLKEAE 190 200 210 220 230 240 QQLERFSVII NTTSVGMSPR VDDMPLSLER LSRETVVSDL IYNPLETKFL REAKQKGAKT 250 260 270 VDGLGMFVNQ GALAFELWTG LRPDREKMRR CVLEQLGG

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB05043.1.
PIR	D83815.
RefSeq	NP_242190.1.
3D structure databases
HSSP	HSSP built from PDB template 1NVT based on UniProtKB Q58484.
ModBase	Search...
Genome annotation databases
GeneID	892076.
GenomeReviews	Gene locus BH1324 in contig BA000004_GR.
KEGG	bha:BH1324.
NMPDR	fig|272558.1.peg.1324.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KD93.
OMA	Q9KD93. AVVCDIV.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1324-MON.
BRENDA	1.1.1.25. 191865.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BACHD

Accession

Primary (citable) accession number: Q9KD93

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)