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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei92Proton donor/acceptorUniRule annotation1
Active sitei155Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei184Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-1435-MONOMER
UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Synonyms:dra
Ordered Locus Names:BH1352
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572231 – 224Deoxyribose-phosphate aldolaseAdd BLAST224

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1352

Structurei

3D structure databases

ProteinModelPortaliQ9KD67
SMRiQ9KD67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105FCI Bacteria
COG0274 LUCA
HOGENOMiHOG000241645
KOiK01619
OMAiMNACIPP
OrthoDBiPOG091H00TV

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00114 DeoC_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
IPR028581 DeoC_typeI
PANTHERiPTHR10889 PTHR10889, 1 hit
PTHR10889:SF1 PTHR10889:SF1, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KD67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSIAQMID HTLLKPNTTE DQIVKLCEEA KEYSFASVCV NPTWVALAAQ
60 70 80 90 100
LLKDAPDVKV CTVIGFPLGA TTPEVKAFET TNAIENGATE VDMVINIGAL
110 120 130 140 150
KDKQYELVGR DIQAVVKAAE GKALTKVIIE TSLLTEEEKK AACELAVKAG
160 170 180 190 200
ADFVKTSTGF SGGGATAEDI ALMRKVVGPN LGVKASGGVR DLSDAKAMID
210 220
AGATRIGASA GVAIVNGERS EGSY
Length:224
Mass (Da):23,362
Last modified:October 1, 2000 - v1
Checksum:i5CC79183BB424502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB05071.1
PIRiH83818
RefSeqiWP_010897517.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB05071; BAB05071; BAB05071
KEGGibha:BH1352

Similar proteinsi

Entry informationi

Entry nameiDEOC_BACHD
AccessioniPrimary (citable) accession number: Q9KD67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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