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Q9KD53

- CDD_BACHD

UniProt

Q9KD53 - CDD_BACHD

Protein

Cytidine deaminase

Gene

cdd

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

    Catalytic activityi

    Cytidine + H2O = uridine + NH3.
    2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Zinc; catalyticBy similarity
    Active sitei55 – 551Proton donorBy similarity
    Metal bindingi86 – 861Zinc; catalyticBy similarity
    Metal bindingi89 – 891Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. cytidine deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBHAL272558:GJC5-1445-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Short name:
    CDA
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:cdd
    Ordered Locus Names:BH1366
    OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
    Taxonomic identifieri272558 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001258: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Cytidine deaminasePRO_0000171676Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272558.BH1366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KD53.
    SMRiQ9KD53. Positions 1-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 10098CMP/dCMP deaminase zinc-bindingAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni42 – 443Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000014707.
    KOiK01489.
    OMAiIADTPRP.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KD53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRQMLIKEA IQAREGAYVP YSRFQVGAAL LMKDGSVIRG ANIENASYGL    50
    TNCAERTALF KAYSEGRRDV VAIAVVADTK RPVPPCGACR QVMAELCPAD 100
    TKVYLGNLQG DIQEITVSEL LPGAFTAEDM ND 132
    Length:132
    Mass (Da):14,301
    Last modified:October 1, 2000 - v1
    Checksum:i3A9800D567088D30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB05085.1.
    PIRiF83820.
    RefSeqiNP_242232.1. NC_002570.2.

    Genome annotation databases

    EnsemblBacteriaiBAB05085; BAB05085; BAB05085.
    GeneIDi892426.
    KEGGibha:BH1366.
    PATRICi18939798. VBIBacHal18977_1417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB05085.1 .
    PIRi F83820.
    RefSeqi NP_242232.1. NC_002570.2.

    3D structure databases

    ProteinModelPortali Q9KD53.
    SMRi Q9KD53. Positions 1-124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272558.BH1366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB05085 ; BAB05085 ; BAB05085 .
    GeneIDi 892426.
    KEGGi bha:BH1366.
    PATRICi 18939798. VBIBacHal18977_1417.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000014707.
    KOi K01489.
    OMAi IADTPRP.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci BHAL272558:GJC5-1445-MONOMER.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
      Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
      Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

    Entry informationi

    Entry nameiCDD_BACHD
    AccessioniPrimary (citable) accession number: Q9KD53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3