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Q9KD53

- CDD_BACHD

UniProt

Q9KD53 - CDD_BACHD

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Protein

Cytidine deaminase

Gene

cdd

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Zinc; catalyticBy similarity
Active sitei55 – 551Proton donorBy similarity
Metal bindingi86 – 861Zinc; catalyticBy similarity
Metal bindingi89 – 891Zinc; catalyticBy similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-1445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminase (EC:3.5.4.5)
Short name:
CDA
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:cdd
Ordered Locus Names:BH1366
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Cytidine deaminasePRO_0000171676Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1366.

Structurei

3D structure databases

ProteinModelPortaliQ9KD53.
SMRiQ9KD53. Positions 1-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 10098CMP/dCMP deaminase zinc-bindingAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni42 – 443Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0295.
HOGENOMiHOG000014707.
KOiK01489.
OMAiIADTPRP.
OrthoDBiEOG6XDH25.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KD53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRQMLIKEA IQAREGAYVP YSRFQVGAAL LMKDGSVIRG ANIENASYGL
60 70 80 90 100
TNCAERTALF KAYSEGRRDV VAIAVVADTK RPVPPCGACR QVMAELCPAD
110 120 130
TKVYLGNLQG DIQEITVSEL LPGAFTAEDM ND
Length:132
Mass (Da):14,301
Last modified:October 1, 2000 - v1
Checksum:i3A9800D567088D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05085.1.
PIRiF83820.
RefSeqiNP_242232.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05085; BAB05085; BAB05085.
GeneIDi892426.
KEGGibha:BH1366.
PATRICi18939798. VBIBacHal18977_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05085.1 .
PIRi F83820.
RefSeqi NP_242232.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9KD53.
SMRi Q9KD53. Positions 1-124.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH1366.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB05085 ; BAB05085 ; BAB05085 .
GeneIDi 892426.
KEGGi bha:BH1366.
PATRICi 18939798. VBIBacHal18977_1417.

Phylogenomic databases

eggNOGi COG0295.
HOGENOMi HOG000014707.
KOi K01489.
OMAi IADTPRP.
OrthoDBi EOG6XDH25.

Enzyme and pathway databases

BioCyci BHAL272558:GJC5-1445-MONOMER.

Family and domain databases

InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view ]
Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiCDD_BACHD
AccessioniPrimary (citable) accession number: Q9KD53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3