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Protein

Cytidine deaminase

Gene

cdd

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Zinc; catalyticBy similarity1
Active sitei55Proton donorBy similarity1
Metal bindingi86Zinc; catalyticBy similarity1
Metal bindingi89Zinc; catalyticBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidine deaminase (EC:3.5.4.5)
Short name:
CDA
Alternative name(s):
Cytidine aminohydrolase
Gene namesi
Name:cdd
Ordered Locus Names:BH1366
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001716761 – 132Cytidine deaminaseAdd BLAST132

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1366.

Structurei

3D structure databases

ProteinModelPortaliQ9KD53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 128CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST128

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni42 – 44Substrate bindingBy similarity3

Sequence similaritiesi

Contains 1 CMP/dCMP-type deaminase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105KG3. Bacteria.
COG0295. LUCA.
HOGENOMiHOG000014707.
KOiK01489.
OMAiERMAKCS.
OrthoDBiPOG091H026Y.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KD53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRQMLIKEA IQAREGAYVP YSRFQVGAAL LMKDGSVIRG ANIENASYGL
60 70 80 90 100
TNCAERTALF KAYSEGRRDV VAIAVVADTK RPVPPCGACR QVMAELCPAD
110 120 130
TKVYLGNLQG DIQEITVSEL LPGAFTAEDM ND
Length:132
Mass (Da):14,301
Last modified:October 1, 2000 - v1
Checksum:i3A9800D567088D30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05085.1.
PIRiF83820.
RefSeqiWP_010897531.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05085; BAB05085; BAB05085.
KEGGibha:BH1366.
PATRICi18939798. VBIBacHal18977_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05085.1.
PIRiF83820.
RefSeqiWP_010897531.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9KD53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH1366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB05085; BAB05085; BAB05085.
KEGGibha:BH1366.
PATRICi18939798. VBIBacHal18977_1417.

Phylogenomic databases

eggNOGiENOG4105KG3. Bacteria.
COG0295. LUCA.
HOGENOMiHOG000014707.
KOiK01489.
OMAiERMAKCS.
OrthoDBiPOG091H026Y.

Family and domain databases

InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMiSSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEiPS00903. CYT_DCMP_DEAMINASES_1. 1 hit.
PS51747. CYT_DCMP_DEAMINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDD_BACHD
AccessioniPrimary (citable) accession number: Q9KD53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.