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Q9KD53

- CDD_BACHD

UniProt

Q9KD53 - CDD_BACHD

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Protein
Cytidine deaminase
Gene
cdd, BH1366
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.

Catalytic activityi

Cytidine + H2O = uridine + NH3.
2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Zinc; catalytic By similarity
Active sitei55 – 551Proton donor By similarity
Metal bindingi86 – 861Zinc; catalytic By similarity
Metal bindingi89 – 891Zinc; catalytic By similarity

GO - Molecular functioni

  1. cytidine deaminase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBHAL272558:GJC5-1445-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Short name:
    CDA
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:cdd
    Ordered Locus Names:BH1366
    OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
    Taxonomic identifieri272558 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001258: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Cytidine deaminase
    PRO_0000171676Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272558.BH1366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KD53.
    SMRiQ9KD53. Positions 1-124.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 10098CMP/dCMP deaminase zinc-binding
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni42 – 443Substrate binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0295.
    HOGENOMiHOG000014707.
    KOiK01489.
    OMAiIADTPRP.
    OrthoDBiEOG6XDH25.

    Family and domain databases

    InterProiIPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEiPS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KD53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRQMLIKEA IQAREGAYVP YSRFQVGAAL LMKDGSVIRG ANIENASYGL    50
    TNCAERTALF KAYSEGRRDV VAIAVVADTK RPVPPCGACR QVMAELCPAD 100
    TKVYLGNLQG DIQEITVSEL LPGAFTAEDM ND 132
    Length:132
    Mass (Da):14,301
    Last modified:October 1, 2000 - v1
    Checksum:i3A9800D567088D30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB05085.1.
    PIRiF83820.
    RefSeqiNP_242232.1. NC_002570.2.

    Genome annotation databases

    EnsemblBacteriaiBAB05085; BAB05085; BAB05085.
    GeneIDi892426.
    KEGGibha:BH1366.
    PATRICi18939798. VBIBacHal18977_1417.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000004 Genomic DNA. Translation: BAB05085.1 .
    PIRi F83820.
    RefSeqi NP_242232.1. NC_002570.2.

    3D structure databases

    ProteinModelPortali Q9KD53.
    SMRi Q9KD53. Positions 1-124.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 272558.BH1366.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB05085 ; BAB05085 ; BAB05085 .
    GeneIDi 892426.
    KEGGi bha:BH1366.
    PATRICi 18939798. VBIBacHal18977_1417.

    Phylogenomic databases

    eggNOGi COG0295.
    HOGENOMi HOG000014707.
    KOi K01489.
    OMAi IADTPRP.
    OrthoDBi EOG6XDH25.

    Enzyme and pathway databases

    BioCyci BHAL272558:GJC5-1445-MONOMER.

    Family and domain databases

    InterProi IPR016192. APOBEC/CMP_deaminase_Zn-bd.
    IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    PROSITEi PS00903. CYT_DCMP_DEAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
      Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
      Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

    Entry informationi

    Entry nameiCDD_BACHD
    AccessioniPrimary (citable) accession number: Q9KD53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: October 1, 2000
    Last modified: May 14, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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