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Q9KD53 (CDD_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytidine deaminase

Short name=CDA
EC=3.5.4.5
Alternative name(s):
Cytidine aminohydrolase
Gene names
Name:cdd
Ordered Locus Names:BH1366
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.

Catalytic activity

Cytidine + H2O = uridine + NH3.

2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

Cofactor

Zinc By similarity.

Sequence similarities

Belongs to the cytidine and deoxycytidylate deaminase family.

Contains 1 CMP/dCMP deaminase zinc-binding domain.

Ontologies

Keywords
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncytidine deaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 132132Cytidine deaminase
PRO_0000171676

Regions

Domain3 – 10098CMP/dCMP deaminase zinc-binding
Region42 – 443Substrate binding By similarity

Sites

Active site551Proton donor By similarity
Metal binding531Zinc; catalytic By similarity
Metal binding861Zinc; catalytic By similarity
Metal binding891Zinc; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KD53 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 3A9800D567088D30

FASTA13214,301
        10         20         30         40         50         60 
MDRQMLIKEA IQAREGAYVP YSRFQVGAAL LMKDGSVIRG ANIENASYGL TNCAERTALF 

        70         80         90        100        110        120 
KAYSEGRRDV VAIAVVADTK RPVPPCGACR QVMAELCPAD TKVYLGNLQG DIQEITVSEL 

       130 
LPGAFTAEDM ND 

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000004 Genomic DNA. Translation: BAB05085.1.
PIRF83820.
RefSeqNP_242232.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9KD53.
SMRQ9KD53. Positions 1-124.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272558.BH1366.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB05085; BAB05085; BAB05085.
GeneID892426.
KEGGbha:BH1366.
PATRIC18939798. VBIBacHal18977_1417.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0295.
HOGENOMHOG000014707.
KOK01489.
OMATIYLSNC.
OrthoDBEOG6XDH25.
ProtClustDBPRK12411.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-1445-MONOMER.

Family and domain databases

InterProIPR016192. APOBEC/CMP_deaminase_Zn-bd.
IPR002125. CMP_dCMP_Zn-bd.
IPR006262. Cyt_deam_tetra.
IPR016193. Cytidine_deaminase-like.
[Graphical view]
PfamPF00383. dCMP_cyt_deam_1. 1 hit.
[Graphical view]
SUPFAMSSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR01354. cyt_deam_tetra. 1 hit.
PROSITEPS00903. CYT_DCMP_DEAMINASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDD_BACHD
AccessionPrimary (citable) accession number: Q9KD53
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: October 1, 2000
Last modified: November 13, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families