Q9KD53 (CDD_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
Short name=CDA
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase

Gene names

Name:	cdd
Ordered Locus Names:	BH1366

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Cytidine deaminase		PRO_0000171676
Regions
	Region	42 – 44	3	Substrate binding By similarity
Sites
	Active site	55	1	Proton donor By similarity
	Metal binding	53	1	Zinc; catalytic By similarity
	Metal binding	86	1	Zinc; catalytic By similarity
	Metal binding	89	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9KD53 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3A9800D567088D30	FASTA	132	14,301
	10 20 30 40 50 60 MDRQMLIKEA IQAREGAYVP YSRFQVGAAL LMKDGSVIRG ANIENASYGL TNCAERTALF 70 80 90 100 110 120 KAYSEGRRDV VAIAVVADTK RPVPPCGACR QVMAELCPAD TKVYLGNLQG DIQEITVSEL 130 LPGAFTAEDM ND

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB05085.1.
PIR	F83820.
RefSeq	NP_242232.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9KD53.
SMR	Q9KD53. Positions 1-124.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000051059; EBBACP00000049698; EBBACG00000051050.
GeneID	892426.
GenomeReviews	Gene locus BH1366 in contig BA000004_GR.
KEGG	bha:BH1366.
NMPDR	fig|272558.1.peg.1366.
PATRIC	18939798. VBIBacHal18977_1417.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002567.
HOGENOM	HBG352939.
OMA	AIPCAIC.
PhylomeDB	Q9KD53.
ProtClustDB	PRK12411.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1366-MONOMER.
Family and domain databases
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR006262. Cyt_deam_tetra. IPR016193. Cytidine_deaminase-like. [Graphical view]
KO	K01489.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit.
TIGRFAMs	TIGR01354. Cyt_deam_tetra. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_BACHD

Accession

Primary (citable) accession number: Q9KD53

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program