ID   GLK_HALH5               Reviewed;         330 AA.
AC   Q9KCZ4;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   27-MAR-2024, entry version 107.
DE   RecName: Full=Glucokinase;
DE            EC=2.7.1.2;
DE   AltName: Full=Glucose kinase;
GN   Name=glcK; Synonyms=glk; OrderedLocusNames=BH1425;
OS   Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae;
OC   Halalkalibacterium (ex Joshi et al. 2022).
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:17825, ChEBI:CHEBI:4167, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61548, ChEBI:CHEBI:456216; EC=2.7.1.2;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. {ECO:0000305}.
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DR   EMBL; BA000004; BAB05144.1; -; Genomic_DNA.
DR   PIR; A83828; A83828.
DR   RefSeq; WP_010897590.1; NC_002570.2.
DR   AlphaFoldDB; Q9KCZ4; -.
DR   SMR; Q9KCZ4; -.
DR   STRING; 272558.gene:10727323; -.
DR   KEGG; bha:BH1425; -.
DR   eggNOG; COG1940; Bacteria.
DR   HOGENOM; CLU_036604_0_1_9; -.
DR   OrthoDB; 9810372at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000600; ROK.
DR   InterPro; IPR004654; ROK_glcA.
DR   NCBIfam; TIGR00744; ROK_glcA_fam; 1.
DR   PANTHER; PTHR18964:SF149; BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE_N-ACETYLMANNOSAMINE KINASE; 1.
DR   PANTHER; PTHR18964; ROK (REPRESSOR, ORF, KINASE) FAMILY; 1.
DR   Pfam; PF00480; ROK; 1.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 1.
DR   PROSITE; PS01125; ROK; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Glycolysis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN           1..330
FT                   /note="Glucokinase"
FT                   /id="PRO_0000095675"
SQ   SEQUENCE   330 AA;  34496 MW;  E5448D6CBD87456F CRC64;
     MSDRWYVGVD VGGTTIKMAF LTTAGEIVDK WEIPTNKQDG GALITTNIAD ALDKRLSGHH
     KSKSDLIGIG LGAPGFIEMD TGFIYHAVNI GWRDFPLKDK LEEETKLPVI VDNDANIAAL
     GEMWKGAGDG AKNMLLITLG TGVGGGIVAN GNILHGVNGM AGEIGHITVI PEGGAPCNCG
     KTGCLETVAS ATGIARIATE GVTEHKESQL ALDYDKHGVL TAKDVFSAAD ASDAFALSVV
     DHIAYYLGFA IANLANALNP EKIVIGGGVS KAGDTLLKPI KQHFEAYALP RVADGAEFRI
     ATLGNDAGVI GGGWLVKQQE NSMEKGNETE
//