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Q9KCP8

- UPPP2_BACHD

UniProt

Q9KCP8 - UPPP2_BACHD

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Protein

Undecaprenyl-diphosphatase 2

Gene
uppP2, bacA2, upk2, BH1521
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-1604-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 2 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene namesi
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:BH1521
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei38 – 5821Helical; Reviewed predictionAdd
BLAST
Transmembranei85 – 10521Helical; Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Reviewed predictionAdd
BLAST
Transmembranei191 – 21121Helical; Reviewed predictionAdd
BLAST
Transmembranei223 – 24321Helical; Reviewed predictionAdd
BLAST
Transmembranei251 – 27121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Undecaprenyl-diphosphatase 2UniRule annotationPRO_0000151100Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1521.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KCP8-1 [UniParc]FASTAAdd to Basket

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MSIIEAIIIG IVQGITEFLP ISSTAHIVIT QFLFDYTFPG FGFEIFLHIA    50
SILAVILYFR KDLLQVIVGF FSYFKDKSEE NRIQFMFAIY IIVATGITGV 100
LGLLLEDLVG AQMKTPPFIA GALIITGTFL IIIERFFVYK DRTVKDMTLK 150
DSIIVGLGQT LAVFPGISRS GATLITALFS GLNKETAVRY SFLLSIPVIL 200
GTSVLAIGDL LDGTLVEQVG GLPLIISFIV TFFFSWLGII WLIDFLKRSK 250
LIYFAFYCFA LAIFVFFYFD HNMTIDLE 278
Length:278
Mass (Da):31,080
Last modified:October 1, 2000 - v1
Checksum:iB121956FB726EF5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB05240.1.
PIRiA83840.
RefSeqiNP_242387.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05240; BAB05240; BAB05240.
GeneIDi890467.
KEGGibha:BH1521.
PATRICi18940142. VBIBacHal18977_1584.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB05240.1 .
PIRi A83840.
RefSeqi NP_242387.1. NC_002570.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH1521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB05240 ; BAB05240 ; BAB05240 .
GeneIDi 890467.
KEGGi bha:BH1521.
PATRICi 18940142. VBIBacHal18977_1584.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci BHAL272558:GJC5-1604-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiUPPP2_BACHD
AccessioniPrimary (citable) accession number: Q9KCP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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