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Protein

L-rhamnose isomerase

Gene

rhaA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-rhamnopyranose = L-rhamnulose.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: L-rhamnose degradation

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from L-rhamnose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-rhamnose isomerase (rhaA)
  2. Rhamnulokinase (rhaB)
  3. no protein annotated in this organism
This subpathway is part of the pathway L-rhamnose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from L-rhamnose, the pathway L-rhamnose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi261ManganeseUniRule annotation1
Metal bindingi293ManganeseUniRule annotation1
Metal bindingi295ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Rhamnose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00541; UER00601.

Names & Taxonomyi

Protein namesi
Recommended name:
L-rhamnose isomeraseUniRule annotation (EC:5.3.1.14UniRule annotation)
Gene namesi
Name:rhaAUniRule annotation
Ordered Locus Names:BH1552
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000905491 – 418L-rhamnose isomeraseAdd BLAST418

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1552.

Structurei

Secondary structure

1418
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 15Combined sources10
Turni16 – 18Combined sources3
Helixi21 – 30Combined sources10
Beta strandi34 – 36Combined sources3
Helixi37 – 39Combined sources3
Turni40 – 43Combined sources4
Helixi70 – 81Combined sources12
Beta strandi84 – 86Combined sources3
Beta strandi89 – 93Combined sources5
Helixi94 – 96Combined sources3
Beta strandi100 – 102Combined sources3
Helixi106 – 108Combined sources3
Helixi111 – 114Combined sources4
Helixi115 – 124Combined sources10
Beta strandi127 – 131Combined sources5
Beta strandi135 – 137Combined sources3
Helixi138 – 140Combined sources3
Beta strandi145 – 147Combined sources3
Helixi151 – 175Combined sources25
Beta strandi179 – 183Combined sources5
Beta strandi188 – 191Combined sources4
Helixi197 – 210Combined sources14
Turni217 – 219Combined sources3
Beta strandi220 – 225Combined sources6
Beta strandi235 – 239Combined sources5
Helixi241 – 250Combined sources10
Beta strandi254 – 258Combined sources5
Helixi268 – 270Combined sources3
Helixi272 – 275Combined sources4
Turni276 – 278Combined sources3
Beta strandi282 – 286Combined sources5
Beta strandi290 – 293Combined sources4
Helixi302 – 313Combined sources12
Turni317 – 319Combined sources3
Beta strandi320 – 324Combined sources5
Beta strandi329 – 331Combined sources3
Helixi333 – 352Combined sources20
Helixi356 – 364Combined sources9
Helixi368 – 377Combined sources10
Helixi378 – 380Combined sources3
Helixi383 – 393Combined sources11
Turni399 – 401Combined sources3
Helixi402 – 412Combined sources11
Turni413 – 416Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P14X-ray2.51A/B/C/D1-418[»]
3UU0X-ray2.70A/B/C/D1-418[»]
3UVAX-ray2.69A/B/C/D1-418[»]
3UXIX-ray2.73A/B/C/D1-418[»]
ProteinModelPortaliQ9KCL9.
SMRiQ9KCL9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KCL9.

Family & Domainsi

Sequence similaritiesi

Belongs to the rhamnose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DKG. Bacteria.
COG4806. LUCA.
HOGENOMiHOG000269679.
KOiK01813.
OMAiVNLHAIY.
OrthoDBiPOG091H0HAV.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00541. RhaA. 1 hit.
InterProiIPR009308. Rhamnose_isomerase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF06134. RhaA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR01748. rhaA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KCL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMKSQFERA KIEYGQWGID VEEALERLKQ VPISIHCWQG DDVGGFELSK
60 70 80 90 100
GELSGGIDVT GDYPGKATTP EELRMDLEKA LSLIPGKHRV NLHAIYAETD
110 120 130 140 150
GKVVERDQLE PRHFEKWVRW AKRHGLGLDF NPTLFSHEKA KDGLTLAHPD
160 170 180 190 200
QAIRQFWIDH CIASRKIGEY FGKELETPCL TNIWIPDGYK DTPSDRLTPR
210 220 230 240 250
KRLKESLDQI FAAEINEAYN LDAVESKLFG IGSESYVVGS HEFYLSYALK
260 270 280 290 300
NDKLCLLDTG HYHPTETVSN KISAMLLFHD KLALHVSRPV RWDSDHVVTF
310 320 330 340 350
DDELREIALE IVRNDALDRV LIGLDFFDAS INRIAAWTIG TRNVIKALLF
360 370 380 390 400
AMLIPHKQLK EWQETGDYTR RLAVLEEFKT YPLGAIWNEY CERMNVPIKE
410
EWLKEIAIYE KEVLLQRH
Length:418
Mass (Da):48,178
Last modified:October 1, 2000 - v1
Checksum:i10165258A259864F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05271.1.
PIRiH83843.
RefSeqiWP_010897715.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05271; BAB05271; BAB05271.
KEGGibha:BH1552.
PATRICi18940208. VBIBacHal18977_1617.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05271.1.
PIRiH83843.
RefSeqiWP_010897715.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P14X-ray2.51A/B/C/D1-418[»]
3UU0X-ray2.70A/B/C/D1-418[»]
3UVAX-ray2.69A/B/C/D1-418[»]
3UXIX-ray2.73A/B/C/D1-418[»]
ProteinModelPortaliQ9KCL9.
SMRiQ9KCL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH1552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB05271; BAB05271; BAB05271.
KEGGibha:BH1552.
PATRICi18940208. VBIBacHal18977_1617.

Phylogenomic databases

eggNOGiENOG4105DKG. Bacteria.
COG4806. LUCA.
HOGENOMiHOG000269679.
KOiK01813.
OMAiVNLHAIY.
OrthoDBiPOG091H0HAV.

Enzyme and pathway databases

UniPathwayiUPA00541; UER00601.

Miscellaneous databases

EvolutionaryTraceiQ9KCL9.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00541. RhaA. 1 hit.
InterProiIPR009308. Rhamnose_isomerase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF06134. RhaA. 1 hit.
[Graphical view]
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR01748. rhaA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRHAA_BACHD
AccessioniPrimary (citable) accession number: Q9KCL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.