Reviewed, UniProtKB/Swiss-Prot Q9KCC7 (GCH1_BACHD)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I
      Short name=GTP-CH-I

Gene names

Name:	folE
Synonyms:	mtrA
Ordered Locus Names:	BH1646

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_0000119384
Sites
	Metal binding	78	1	Zinc By similarity
	Metal binding	81	1	Zinc By similarity
	Metal binding	150	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9KCC7-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: FB80F7E527641EFD	FASTA	188	20,499
	10 20 30 40 50 60 MSKVDHEKIQ QAVVMILEAI GEDPAREGLE DTPKRVAKMY EEVFAGLNQD PKEHFATIFG 70 80 90 100 110 120 EDHEELVLVK DIPFFSMCEH HLVPFFGKAH VGYIPKGGKV TGLSKLARAV EAVARRPQLQ 130 140 150 160 170 180 ERITSTVADA LVETLEPHGV IVVVEAEHMC MTMRGVKKPG AATVTSAVRG TFANDAAARA EVLSLIKG

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB05365.1.
PIR	F83855.
RefSeq	NP_242512.1.
3D structure databases
HSSP	HSSP built from PDB template 1FB1 based on UniProtKB P30793.
ModBase	Search...
Genome annotation databases
GeneID	893842.
GenomeReviews	Gene locus BH1646 in contig BA000004_GR.
KEGG	bha:BH1646.
NMPDR	fig|272558.1.peg.1646.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KCC7.
OMA	ARIVEMF.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1646-MON.
BRENDA	3.5.4.16. 191865.
Family and domain databases
HAMAP	MF_00223. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
ProDom	PD003330. GTP_cyclohydroI. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_BACHD

Accession

Primary (citable) accession number: Q9KCC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)