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Protein

Transcription attenuation protein MtrB

Gene

mtrB

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Required for transcription attenuation control in the Trp operon. This trans-acting factor seems to recognize a 10 bases nucleotide sequence in the Trp leader transcript causing transcription termination. Binds the leader RNA only in presence of L-tryptophan (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription attenuation protein MtrB
Alternative name(s):
Trp RNA-binding attenuation protein
Short name:
TRAP
Tryptophan RNA-binding attenuator protein
Gene namesi
Name:mtrB
Ordered Locus Names:BH1647
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060251 – 76Transcription attenuation protein MtrBAdd BLAST76

Interactioni

Subunit structurei

Oligomer of 11 identical subunits arranged in doughnut-like structure.By similarity

Protein-protein interaction databases

STRINGi272558.BH1647.

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Beta strandi19 – 25Combined sources7
Beta strandi32 – 38Combined sources7
Beta strandi43 – 47Combined sources5
Beta strandi50 – 65Combined sources16
Beta strandi68 – 71Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZZLX-ray1.67A/B/C7-76[»]
ProteinModelPortaliQ9KCC6.
SMRiQ9KCC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MtrB family.Curated

Phylogenomic databases

eggNOGiENOG4105WP2. Bacteria.
ENOG411234W. LUCA.
HOGENOMiHOG000245485.
KOiK06285.
OMAiDTKFHHT.
OrthoDBiPOG091H0V7N.

Family and domain databases

Gene3Di2.60.40.50. 1 hit.
HAMAPiMF_00798. Trp_attenuator. 1 hit.
InterProiIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamiPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSiPR00687. TRPRNAAP.
SUPFAMiSSF51219. SSF51219. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KCC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGDNSNFF VIKAKENGVN VFGMTRGTDT RFHHSEKLDK GEVMIAQFTE
60 70
HTSAVKIRGK AIIQTSYGTL DTEKDE
Length:76
Mass (Da):8,493
Last modified:October 1, 2000 - v1
Checksum:iB9FEB4A0CCDF9AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05366.1.
PIRiG83855.
RefSeqiWP_010897809.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05366; BAB05366; BAB05366.
KEGGibha:BH1647.
PATRICi18940412. VBIBacHal18977_1719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05366.1.
PIRiG83855.
RefSeqiWP_010897809.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZZLX-ray1.67A/B/C7-76[»]
ProteinModelPortaliQ9KCC6.
SMRiQ9KCC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH1647.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB05366; BAB05366; BAB05366.
KEGGibha:BH1647.
PATRICi18940412. VBIBacHal18977_1719.

Phylogenomic databases

eggNOGiENOG4105WP2. Bacteria.
ENOG411234W. LUCA.
HOGENOMiHOG000245485.
KOiK06285.
OMAiDTKFHHT.
OrthoDBiPOG091H0V7N.

Family and domain databases

Gene3Di2.60.40.50. 1 hit.
HAMAPiMF_00798. Trp_attenuator. 1 hit.
InterProiIPR000824. MtrB.
IPR016031. Trp_RNA-bd_attenuator-like_dom.
IPR023558. Trp_RNA-bd_attenuator_dom.
[Graphical view]
PfamiPF02081. TrpBP. 1 hit.
[Graphical view]
PRINTSiPR00687. TRPRNAAP.
SUPFAMiSSF51219. SSF51219. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMTRB_BACHD
AccessioniPrimary (citable) accession number: Q9KCC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.