Reviewed, UniProtKB/Swiss-Prot Q9KCB6 (AROB_BACHD)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BH1657

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	NAD By similarity. Divalent metal cations By similarity.
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	3-dehydroquinate synthase HAMAP MF_00110		PRO_0000140709

Sequences

	Sequence		Length	Mass (Da)
	Q9KCB6-1 [UniParc]. Last modified November 14, 2003. Version 2. Checksum: 0920D0E004561848	FASTA	361	39,686
	10 20 30 40 50 60 MSVLTVHTSS KVYNVTVKSG VLSQIGSYIA PLRPSAILIV TDDQVADLYL DTVKSSLHNL 70 80 90 100 110 120 APLHAVVLPN GEETKSFDNY YALQTAALEY GLDRKSMIIA LGGGVIGDLA GFVAATYMRG 130 140 150 160 170 180 IAYVQVPTTL LAHDSSVGGK VAINHPLGKN MIGAFHQPEA VLYDPQVFAT LPEREWRSGF 190 200 210 220 230 240 AEVVKHGLIK DAAFYAWLQK YINDFSRIQG EIAEELLLRS IQVKANIVAA DEKEKGERAL 250 260 270 280 290 300 LNLGHTLGHA IEAELGYGKI THGEAVVIGI IFAMKLSEKV YHQSLPIQDL EKWLKFLGYE 310 320 330 340 350 360 TRIPKGLDTG ALIGTMKKDK KVERGVIRFV LLEEVGHAVI KEVDEQLIRE LLNVEIEEET T

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB05376.1. Different initiation.
PIR	A83857.
RefSeq	NP_242523.1.
3D structure databases
HSSP	HSSP built from PDB template 1DQS based on UniProtKB P07547.
ModBase	Search...
Genome annotation databases
GeneID	892389.
GenomeReviews	Gene locus BH1657 in contig BA000004_GR.
KEGG	bha:BH1657.
NMPDR	fig|272558.1.peg.1657.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KCB6.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1657-MON.
BRENDA	4.2.3.4. 191865.
Family and domain databases
HAMAP	MF_00110. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACHD

Accession

Primary (citable) accession number: Q9KCB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	November 14, 2003
Last modified:	September 22, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)