Reviewed, UniProtKB/Swiss-Prot Q9KCB2 (TRPC_BACHD)

Names and origin

Protein names

Recommended name:
    Indole-3-glycerol phosphate synthase
      Short name=IGPS
    EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BH1661

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134
Sequence similarities	Belongs to the trpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	Indole-3-glycerol phosphate synthase HAMAP MF_00134		PRO_0000154210

Sequences

	Sequence		Length	Mass (Da)
	Q9KCB2-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CF9E050395D6E714	FASTA	257	28,435
	10 20 30 40 50 60 MLDTILQTKR EEIERLALPE QVEVKKVSLY DALRKPNRSL GLLAEVKKAS PSKGLIRADF 70 80 90 100 110 120 HPVEIGKSYE AAGADAISVL TDETYFQGHR DYLTKVKQAV NIPVLRKDFI IDRAQILESV 130 140 150 160 170 180 RIGADAILLI VSTIPTTRLK ELYDEAHELG LECLVEVHSE EEIAELFSAF TPTLIGVNNR 190 200 210 220 230 240 NLKTFETDVA QTEKMAQVIP HGTMFLSESG LYTYDDLQRV KRAGATGVLV GESLMRASSP 250 EEGIQHLFGG EPVATDA

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB05380.1.
PIR	E83857.
RefSeq	NP_242527.1.
3D structure databases
SMR	Q9KCB2. Positions 1-249.
ModBase	Search...
Genome annotation databases
GeneID	892336.
GenomeReviews	Gene locus BH1661 in contig BA000004_GR.
KEGG	bha:BH1661.
NMPDR	fig|272558.1.peg.1661.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
OMA	PLLCKDF.
PhylomeDB	Q9KCB2.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1661-MONOMER.
BRENDA	4.1.1.48. 191865.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACHD

Accession

Primary (citable) accession number: Q9KCB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)