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Q9KCA6 (AROA1_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-phosphoshikimate 1-carboxyvinyltransferase 1
EC=2.5.1.19
Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase 1
Short name=EPSP synthase 1
Short name=EPSPS 1
Gene names
Name:aroA1
Synonyms:aroE
Ordered Locus Names:BH1667
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210

Subunit structure

Monomer By similarity. HAMAP MF_00210

Subcellular location

Cytoplasm By similarity HAMAP MF_00210.

Sequence similarities

Belongs to the EPSP synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-phosphoshikimate 1-carboxyvinyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4314313-phosphoshikimate 1-carboxyvinyltransferase 1 HAMAP MF_00210
PRO_0000088222

Secondary structure

1 ..................................................................... 431
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KCA6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 12F4FFBE7BA0743D

FASTA43145,485
        10         20         30         40         50         60 
MENKTVIPHA KGLKGTIKVP GDKSISHRAV MFGALAKGTT TVEGFLPGAD CLSTISCFQK 

        70         80         90        100        110        120 
LGVSIEQAEE RVTVKGKGWD GLREPSDILD VGNSGTTTRL ILGILSTLPF HSVIIGDESI 

       130        140        150        160        170        180 
GKRPMKRVTE PLKSMGAQID GRDHGNLTPL SIRGGQLKGI DFHSPVASAQ MKSAILLAGL 

       190        200        210        220        230        240 
RAEGKTSVTE PAKTRDHTER MLEAFGVNIE KDGLTVSIEG GQMLTGQHVV VPGDISSAAF 

       250        260        270        280        290        300 
FLVAGAMVPH SRITLTNVGI NPTRAGILEV LKQMGATLAM ENERVQGGEP VADLTIETSV 

       310        320        330        340        350        360 
LQGVEIGGDI IPRLIDEIPI IAVLATQASG RTVIKDAEEL KVKETNRIDT VVSELTKLGA 

       370        380        390        400        410        420 
SIHATDDGMI IEGPTPLKGG VTVSSHGDHR IGMAMAIAAL LAEKPVTVEG TEAIAVSYPS 

       430 
FFDHLDRLKS E

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB05386.1.
PIRC83858.
RefSeqNP_242533.1. NC_002570.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3RMTX-ray2.80A/B/C/D1-431[»]
ProteinModelPortalQ9KCA6.
SMRQ9KCA6. Positions 8-430.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000051716; EBBACP00000050355; EBBACG00000051707.
GeneID891569.
GenomeReviewsGene locus BH1667 in contig BA000004_GR.
KEGGbha:BH1667.
NMPDRfig|272558.1.peg.1667.
PATRIC18940452. VBIBacHal18977_1739.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000001036.
HOGENOMHBG646626.
OMALECANIS.
PhylomeDBQ9KCA6.
ProtClustDBPRK02427.

Enzyme and pathway databases

BioCycBHAL272558:BH1667-MONOMER.

Family and domain databases

HAMAPMF_00210. EPSP_synth.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR006264. EPSP_synthase.
IPR023193. EPSP_synthase_CS.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00800.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000505. EPSPS. 1 hit.
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01356. AroA. 1 hit.
PROSITEPS00104. EPSP_SYNTHASE_1. 1 hit.
PS00885. EPSP_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROA1_BACHD
AccessionPrimary (citable) accession number: Q9KCA6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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