Reviewed, UniProtKB/Swiss-Prot Q9KCA6 (AROA1_BACHD)

Names and origin

Protein names

Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferase 1
    EC=2.5.1.19
Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthase 1
      Short name=EPSP synthase 1
      Short name=EPSPS 1

Gene names

Name:	aroA1
Synonyms:	aroE
Ordered Locus Names:	BH1667

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm Probable HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	3-phosphoshikimate 1-carboxyvinyltransferase 1 HAMAP MF_00210		PRO_0000088222

Sequences

	Sequence		Length	Mass (Da)
	Q9KCA6-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 12F4FFBE7BA0743D	FASTA	431	45,485
	10 20 30 40 50 60 MENKTVIPHA KGLKGTIKVP GDKSISHRAV MFGALAKGTT TVEGFLPGAD CLSTISCFQK 70 80 90 100 110 120 LGVSIEQAEE RVTVKGKGWD GLREPSDILD VGNSGTTTRL ILGILSTLPF HSVIIGDESI 130 140 150 160 170 180 GKRPMKRVTE PLKSMGAQID GRDHGNLTPL SIRGGQLKGI DFHSPVASAQ MKSAILLAGL 190 200 210 220 230 240 RAEGKTSVTE PAKTRDHTER MLEAFGVNIE KDGLTVSIEG GQMLTGQHVV VPGDISSAAF 250 260 270 280 290 300 FLVAGAMVPH SRITLTNVGI NPTRAGILEV LKQMGATLAM ENERVQGGEP VADLTIETSV 310 320 330 340 350 360 LQGVEIGGDI IPRLIDEIPI IAVLATQASG RTVIKDAEEL KVKETNRIDT VVSELTKLGA 370 380 390 400 410 420 SIHATDDGMI IEGPTPLKGG VTVSSHGDHR IGMAMAIAAL LAEKPVTVEG TEAIAVSYPS 430 FFDHLDRLKS E

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB05386.1.
PIR	C83858.
RefSeq	NP_242533.1.
3D structure databases
SMR	Q9KCA6. Positions 8-430.
ModBase	Search...
Genome annotation databases
GeneID	891569.
GenomeReviews	Gene locus BH1667 in contig BA000004_GR.
KEGG	bha:BH1667.
NMPDR	fig|272558.1.peg.1667.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG646626.
OMA	NITIETS.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1667-MONOMER.
BRENDA	2.5.1.19. 191865.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR016228. EPSP_synthase. IPR001986. EPSP_synthase_core. IPR006264. EPSP_synthase_subgroup. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
TIGRFAMs	TIGR01356. aroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA1_BACHD

Accession

Primary (citable) accession number: Q9KCA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)