Reviewed, UniProtKB/Swiss-Prot Q9KC93 (DAPB_BACHD)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	BH1680

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000141410

Sequences

	Sequence		Length	Mass (Da)
	Q9KC93-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D6E30FC89DEAFE4F	FASTA	264	28,754
	10 20 30 40 50 60 MIKVAVAGPR GKMGREAVKM IHEADTLELV AVVDSKHDGM LVRQLDGLPP SDAPVYNELE 70 80 90 100 110 120 RCLTSQTIDV LVDLTTPAHG KRHMEIALDH GVRPVVGTTG FTDEDITNLR KKAEEKGIGA 130 140 150 160 170 180 IIAPNFAIGA ILMMKFAQTA AKYLPDVEII EMHHDRKLDA PSGTALKTAQ LISEVRKAKQ 190 200 210 220 230 240 QGHPDETEEL KGARGADFEG MSIHSVRLPG LVAHQEVLFG GVGQTLKIRH DSMNRESFMP 250 260 GVKLSIETVM GIDTLVYGLE NIIE

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB05399.1.
PIR	H83859.
RefSeq	NP_242546.1.
3D structure databases
SMR	Q9KC93. Positions 2-264.
ModBase	Search...
Genome annotation databases
GeneID	890717.
GenomeReviews	Gene locus BH1680 in contig BA000004_GR.
KEGG	bha:BH1680.
NMPDR	fig|272558.1.peg.1680.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG594002.
OMA	EEIKPDC.
PhylomeDB	Q9KC93.
Enzyme and pathway databases
BioCyc	BHAL272558:BH1680-MONOMER.
BRENDA	1.3.1.26. 191865.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_BACHD

Accession

Primary (citable) accession number: Q9KC93

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)