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Reviewed, UniProtKB/Swiss-Prot Q9KBR3 (G1PDH_BACHD)

Last modified November 3, 2009. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glycerol-1-phosphate dehydrogenase [NAD(P)+]
      Short name=G1P dehydrogenase
      Short name=G1PDH
    EC=1.1.1.261
Alternative name(s):
    sn-glycerol-1-phosphate dehydrogenase
    Enantiomeric glycerophosphate synthase
Gene names
Name: egsA
Ordered Locus Names: BH1862
OrganismBacillus halodurans [Complete proteome] [HAMAP]
Taxonomic identifier86665 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

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Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol-1-phosphate (G1P). The G1P thus generated is probably used for the synthesis of phosphoglycerolipids in Gram-positive bacterial species By similarity.

Catalytic activity

sn-glycerol-1-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H. HAMAP MF_00497

Cofactor

Binds 1 nickel ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the glycerol-1-phosphate dehydrogenase family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Glycerol-1-phosphate dehydrogenase [NAD(P)+] HAMAP MF_00497
PRO_0000350637

Regions

Nucleotide binding118 – 1225NAD By similarity
Nucleotide binding140 – 1434NAD By similarity

Sites

Metal binding1921Nickel; catalytic By similarity
Metal binding2721Nickel; catalytic By similarity
Metal binding2921Nickel; catalytic By similarity
Binding site561NAD By similarity
Binding site1451Substrate By similarity
Binding site1491NAD By similarity
Binding site1921Substrate By similarity
Binding site2761Substrate By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9KBR3-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: EAFE42EB49629D73

FASTA39943,585
        10         20         30         40         50         60 
MNHLLKQAKR VASECECGHE HQWIEMDELQ LGRNAINYLP EYLHEKGLLH VTIVADANTY 

        70         80         90        100        110        120 
AVAGQLVAQL LKGRGIDVEN CILKEQGALT LLADEHGLGQ LVIGAAKETD VFLAVGAGTI 

       130        140        150        160        170        180 
HDLTRIASYK FGKPFIAIPT APSVDGFTSM GAPVIRDGVK ITFQTQAPIA LFADLDFLTQ 

       190        200        210        220        230        240 
APRSMVAAGF GDMLGKSTSL VDWQVSHMLN DEPFCPAVFH MTKSALTMCM EHADEIAACN 

       250        260        270        280        290        300 
EQGIRLLTEA LIMSGLAMLI FGHSHPASGA EHHLSHYWEM AFLRSGGTQP LHGAKVGYAT 

       310        320        330        340        350        360 
MLISALYKNE ARKKIETFQG EGSPLVNSIH KHRERLLMLI DTIPESSDIQ RLLESVGGAV 

       370        380        390 
KSADLALADS LEDEALEKAH KLRERCTLLY CLNEHLKTS

« Hide

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References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

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Cross-references

Sequence databases

BA000004 Genomic DNA. Translation: BAB05581.1.
PIRF83882.
RefSeqNP_242728.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID890490.
GenomeReviewsGene locus BH1862 in contig BA000004_GR.
KEGGbha:BH1862.
NMPDRfig|272558.1.peg.1862.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9KBR3.
OMALHGAKVG.

Enzyme and pathway databases

BioCycBHAL272558:BH1862-MONOMER.

Family and domain databases

HAMAPMF_00497.
[Tree]
InterProIPR002658. DHQ_synth_AroB.
[Graphical view]
PfamPF01761. DHQ_synthase. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameG1PDH_BACHD
AccessionPrimary (citable) accession number: Q9KBR3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: October 1, 2000
Last modified: November 3, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents