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Protein

L-arabinose isomerase

Gene

araA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of L-arabinose to L-ribulose.UniRule annotation

Catalytic activityi

L-arabinose = L-ribulose.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Pathwayi: L-arabinose degradation via L-ribulose

This protein is involved in step 1 of the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (bacterial route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-arabinose isomerase (araA)
  2. Ribulokinase (araB)
  3. L-ribulose-5-phosphate 4-epimerase (araD)
This subpathway is part of the pathway L-arabinose degradation via L-ribulose, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-xylulose 5-phosphate from L-arabinose (bacterial route), the pathway L-arabinose degradation via L-ribulose and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi306 – 3061ManganeseUniRule annotation
Metal bindingi331 – 3311ManganeseUniRule annotation
Metal bindingi348 – 3481ManganeseUniRule annotation
Metal bindingi447 – 4471ManganeseUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Arabinose catabolism, Carbohydrate metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-1957-MONOMER.
BRENDAi5.3.1.4. 661.
SABIO-RKQ9KBQ2.
UniPathwayiUPA00145; UER00565.

Names & Taxonomyi

Protein namesi
Recommended name:
L-arabinose isomeraseUniRule annotation (EC:5.3.1.4UniRule annotation)
Gene namesi
Name:araAUniRule annotation
Ordered Locus Names:BH1873
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497L-arabinose isomerasePRO_0000198379Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH1873.

Structurei

3D structure databases

ProteinModelPortaliQ9KBQ2.
SMRiQ9KBQ2. Positions 1-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arabinose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAC. Bacteria.
COG2160. LUCA.
HOGENOMiHOG000252817.
KOiK01804.
OMAiLMEDYTY.
OrthoDBiPOG091H078Z.

Family and domain databases

HAMAPiMF_00519. Arabinose_Isome. 1 hit.
InterProiIPR024664. Ara_Isoase_C.
IPR004216. Fuc/Ara_isomerase_C.
IPR009015. Fucose_isomerase_N/cen.
IPR003762. Lara_isomerase.
[Graphical view]
PfamiPF11762. Arabinose_Iso_C. 1 hit.
PF02610. Arabinose_Isome. 1 hit.
[Graphical view]
PIRSFiPIRSF001478. L-ara_isomerase. 1 hit.
ProDomiPD018364. Lara_isomerase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KBQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQTKPYTFW FITGSQHLYG EDAIEQVRQH SQTMVEKLNK IGELPYTIEL
60 70 80 90 100
KEVLTTPDAI RKMVIAANSD DDCAGMITWM HTFSPAKMWI NGLKQLKKPL
110 120 130 140 150
LHLHTQFNRE IPYDDIDMDF MNLNQSAHGD REYGHIGARL NISRKVIVGH
160 170 180 190 200
WQNNDVQERL GAWMRTAAAF VDGHHLKVAR FGDNMREVAV TEGDKVEAQI
210 220 230 240 250
QFGWSITAFG IGDLVEKMKA VSEDEVRRLF DEYQELYRLS PSILEQDEVK
260 270 280 290 300
AAVLEQAKME LALKEFLEEG GYTAFTTNFE DLHGMKQLPG LAVQRLMAEG
310 320 330 340 350
YGFGGEGDWK TAALLRMMKI IADGKGTSFM EDYTYHLAEG NELVLGSHML
360 370 380 390 400
EICPTIAANQ PEIQVHPLGI GGKEDPARLV FDGADGPALN ASLIDLGHRF
410 420 430 440 450
RLVVNEVEAI KPERDMPKLP VAKVLWKCKP SLSEATEAWI HAGGAHHTVF
460 470 480 490
SFEVTPEQLY DWATLADIEV VFINDKTDVL QFQQQLQWNE AFRRLFK
Length:497
Mass (Da):56,320
Last modified:October 1, 2000 - v1
Checksum:i637D660D25E3F5A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05592.1.
PIRiA83884.
RefSeqiWP_010898034.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05592; BAB05592; BAB05592.
KEGGibha:BH1873.
PATRICi18940876. VBIBacHal18977_1951.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05592.1.
PIRiA83884.
RefSeqiWP_010898034.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9KBQ2.
SMRiQ9KBQ2. Positions 1-495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH1873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB05592; BAB05592; BAB05592.
KEGGibha:BH1873.
PATRICi18940876. VBIBacHal18977_1951.

Phylogenomic databases

eggNOGiENOG4105CAC. Bacteria.
COG2160. LUCA.
HOGENOMiHOG000252817.
KOiK01804.
OMAiLMEDYTY.
OrthoDBiPOG091H078Z.

Enzyme and pathway databases

UniPathwayiUPA00145; UER00565.
BioCyciBHAL272558:GJC5-1957-MONOMER.
BRENDAi5.3.1.4. 661.
SABIO-RKQ9KBQ2.

Family and domain databases

HAMAPiMF_00519. Arabinose_Isome. 1 hit.
InterProiIPR024664. Ara_Isoase_C.
IPR004216. Fuc/Ara_isomerase_C.
IPR009015. Fucose_isomerase_N/cen.
IPR003762. Lara_isomerase.
[Graphical view]
PfamiPF11762. Arabinose_Iso_C. 1 hit.
PF02610. Arabinose_Isome. 1 hit.
[Graphical view]
PIRSFiPIRSF001478. L-ara_isomerase. 1 hit.
ProDomiPD018364. Lara_isomerase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARAA_BACHD
AccessioniPrimary (citable) accession number: Q9KBQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.