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Protein

2-oxoglutarate dehydrogenase E1 component

Gene

odhA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-HAMAP
  2. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 componentUniRule annotation (EC:1.2.4.2UniRule annotation)
Alternative name(s):
Alpha-ketoglutarate dehydrogenaseUniRule annotation
Gene namesi
Name:odhAUniRule annotation
Ordered Locus Names:BH2206
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9459452-oxoglutarate dehydrogenase E1 componentPRO_0000162165Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2206.

Structurei

3D structure databases

ProteinModelPortaliQ9KAT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-ketoglutarate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KAT1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSKEHTSEE PWQGFYGPNL GVAVELYEEY QKDPNAVDDE LREAFEKWGP
60 70 80 90 100
PPATAPERTQ STFTAASITD PDVIKKFVGA VKLADHIRAF GHLAADIQPI
110 120 130 140 150
LKEQRREDMF DLDRFGLTES DIRSVPVDLL CPYAPAHVKN GLDAINHLKE
160 170 180 190 200
VYTKTIAFEF VHVTDEEERK WLNRMIESGL YLPNLSTEQR KSLLKRLTDV
210 220 230 240 250
EGFEKFLHRT FVGQKRFSIE GLDTLVPMLD EVVREAVHEG TTNVMIGMAH
260 270 280 290 300
RGRLNVLAHV LNKPYEMIFA EFLHSLNKDL FPSEGSIGIN YGWTGDVKYH
310 320 330 340 350
LGADRQIRDE NTAEARLTLA NNPSHLEFVS PIVEGYARAA QEDRTSPGAP
360 370 380 390 400
EQDIMKAYSI LIHGDAAFPG QGVVTETLNL SRLTGYQTGG SLHIIANNNI
410 420 430 440 450
GFTTETFDSR STLYSSDPAK GFEIPIVHVN ADDPEACLAA VHLAFQYRKR
460 470 480 490 500
FKKDFLIDLI GYRRFGHNEM DEPAVTQPGV YQIIRKHPTV RELYSKQLVK
510 520 530 540 550
KGLIDEQTVK QLDDEVQDKL QSVYEETLRN RTDEHLPDTP PVEVVNGLPK
560 570 580 590 600
LDTGVQSETL KAINNELLEW PESFSVNPKL EKILKRRLNV FDGDGKVDWA
610 620 630 640 650
LAETLAFATI LHDGTPIRLT GQDSERGTFA HRHLVLHDSR TNDVHSPLQS
660 670 680 690 700
FRHANASFAV HNSPLSEMAI VGFEYGYNVF APETLVLWEA QFGDFANGAQ
710 720 730 740 750
VMFDQWVSAG RAKWGQKSGL VCLLPHGYEG QGPEHSSARL ERFLVLAAEN
760 770 780 790 800
NWTIANCTSA AQYFHILRRQ AAILNTDSVR PLIMMTPKSL LRNQKVASSV
810 820 830 840 850
EELTTGRFKT VLEQPNLGES HEKVERIVLC SGKIAIDLQD RIEKEADKDW
860 870 880 890 900
DWVHIVRVEQ LYPFPKEPLQ EIFARYPNVK EIVWSQEEPR NMGAWPFVQS
910 920 930 940
KIRRAAPNGI NVRYEGRTYR SSPAEGDPII HKQEQERIVT ETLTR
Length:945
Mass (Da):106,970
Last modified:October 1, 2000 - v1
Checksum:iDF3D694B15EEAA5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05925.1.
PIRiF83925.
RefSeqiNP_243072.1. NC_002570.2.
WP_010898362.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05925; BAB05925; BAB05925.
GeneIDi891738.
KEGGibha:BH2206.
PATRICi18941582. VBIBacHal18977_2304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB05925.1.
PIRiF83925.
RefSeqiNP_243072.1. NC_002570.2.
WP_010898362.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9KAT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB05925; BAB05925; BAB05925.
GeneIDi891738.
KEGGibha:BH2206.
PATRICi18941582. VBIBacHal18977_2304.

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiEHSNARP.
OrthoDBiEOG6V1M1F.

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2290-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiODO1_BACHD
AccessioniPrimary (citable) accession number: Q9KAT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.