Reviewed, UniProtKB/Swiss-Prot Q9KAT1 (ODO1_BACHD)

Names and origin

Protein names

Recommended name:
    2-oxoglutarate dehydrogenase E1 component
    EC=1.2.4.2
Alternative name(s):
    Alpha-ketoglutarate dehydrogenase

Gene names

Name:	odhA
Ordered Locus Names:	BH2206

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	945 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.
Catalytic activity	2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP MF_01169
Cofactor	Thiamine pyrophosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Keywords
Biological process	Glycolysis
Ligand	Thiamine pyrophosphate
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	oxoglutarate dehydrogenase (succinyl-transferring) activity Inferred from electronic annotation. Source: HAMAP thiamin pyrophosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 945	945	2-oxoglutarate dehydrogenase E1 component HAMAP MF_01169		PRO_0000162165

Sequences

	Sequence		Length	Mass (Da)
	Q9KAT1-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: DF3D694B15EEAA5C	FASTA	945	106,970
	10 20 30 40 50 60 MSSKEHTSEE PWQGFYGPNL GVAVELYEEY QKDPNAVDDE LREAFEKWGP PPATAPERTQ 70 80 90 100 110 120 STFTAASITD PDVIKKFVGA VKLADHIRAF GHLAADIQPI LKEQRREDMF DLDRFGLTES 130 140 150 160 170 180 DIRSVPVDLL CPYAPAHVKN GLDAINHLKE VYTKTIAFEF VHVTDEEERK WLNRMIESGL 190 200 210 220 230 240 YLPNLSTEQR KSLLKRLTDV EGFEKFLHRT FVGQKRFSIE GLDTLVPMLD EVVREAVHEG 250 260 270 280 290 300 TTNVMIGMAH RGRLNVLAHV LNKPYEMIFA EFLHSLNKDL FPSEGSIGIN YGWTGDVKYH 310 320 330 340 350 360 LGADRQIRDE NTAEARLTLA NNPSHLEFVS PIVEGYARAA QEDRTSPGAP EQDIMKAYSI 370 380 390 400 410 420 LIHGDAAFPG QGVVTETLNL SRLTGYQTGG SLHIIANNNI GFTTETFDSR STLYSSDPAK 430 440 450 460 470 480 GFEIPIVHVN ADDPEACLAA VHLAFQYRKR FKKDFLIDLI GYRRFGHNEM DEPAVTQPGV 490 500 510 520 530 540 YQIIRKHPTV RELYSKQLVK KGLIDEQTVK QLDDEVQDKL QSVYEETLRN RTDEHLPDTP 550 560 570 580 590 600 PVEVVNGLPK LDTGVQSETL KAINNELLEW PESFSVNPKL EKILKRRLNV FDGDGKVDWA 610 620 630 640 650 660 LAETLAFATI LHDGTPIRLT GQDSERGTFA HRHLVLHDSR TNDVHSPLQS FRHANASFAV 670 680 690 700 710 720 HNSPLSEMAI VGFEYGYNVF APETLVLWEA QFGDFANGAQ VMFDQWVSAG RAKWGQKSGL 730 740 750 760 770 780 VCLLPHGYEG QGPEHSSARL ERFLVLAAEN NWTIANCTSA AQYFHILRRQ AAILNTDSVR 790 800 810 820 830 840 PLIMMTPKSL LRNQKVASSV EELTTGRFKT VLEQPNLGES HEKVERIVLC SGKIAIDLQD 850 860 870 880 890 900 RIEKEADKDW DWVHIVRVEQ LYPFPKEPLQ EIFARYPNVK EIVWSQEEPR NMGAWPFVQS 910 920 930 940 KIRRAAPNGI NVRYEGRTYR SSPAEGDPII HKQEQERIVT ETLTR

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB05925.1.
PIR	F83925.
RefSeq	NP_243072.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	891738.
GenomeReviews	Gene locus BH2206 in contig BA000004_GR.
KEGG	bha:BH2206.
NMPDR	fig|272558.1.peg.2206.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KAT1.
OMA	Q9KAT1. EGDEPAF.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2206-MON.
BRENDA	1.2.4.2. 191865.
Family and domain databases
HAMAP	MF_01169. [Tree]
InterPro	IPR011603. 2oxoglutarate_DH_E1. IPR001017. DH_E1. IPR005475. Transketolase_central-reg. [Graphical view]
PANTHER	PTHR23152. 2oxoglutarate_DH_E1. 1 hit.
Pfam	PF00676. E1_dh. 1 hit. PF02779. Transket_pyr. 1 hit. [Graphical view]
PIRSF	PIRSF000157. Oxoglu_dh_E1. 1 hit.
TIGRFAMs	TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ODO1_BACHD

Accession

Primary (citable) accession number: Q9KAT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)