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Q9KAT1 (ODO1_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-oxoglutarate dehydrogenase E1 component

EC=1.2.4.2
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene names
Name:odhA
Ordered Locus Names:BH2206
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length945 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. HAMAP-Rule MF_01169

Catalytic activity

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2. HAMAP-Rule MF_01169

Cofactor

Thiamine pyrophosphate By similarity. HAMAP-Rule MF_01169

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01169

Sequence similarities

Belongs to the alpha-ketoglutarate dehydrogenase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9459452-oxoglutarate dehydrogenase E1 component HAMAP-Rule MF_01169
PRO_0000162165

Sequences

Sequence LengthMass (Da)Tools
Q9KAT1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: DF3D694B15EEAA5C

FASTA945106,970
        10         20         30         40         50         60 
MSSKEHTSEE PWQGFYGPNL GVAVELYEEY QKDPNAVDDE LREAFEKWGP PPATAPERTQ 

        70         80         90        100        110        120 
STFTAASITD PDVIKKFVGA VKLADHIRAF GHLAADIQPI LKEQRREDMF DLDRFGLTES 

       130        140        150        160        170        180 
DIRSVPVDLL CPYAPAHVKN GLDAINHLKE VYTKTIAFEF VHVTDEEERK WLNRMIESGL 

       190        200        210        220        230        240 
YLPNLSTEQR KSLLKRLTDV EGFEKFLHRT FVGQKRFSIE GLDTLVPMLD EVVREAVHEG 

       250        260        270        280        290        300 
TTNVMIGMAH RGRLNVLAHV LNKPYEMIFA EFLHSLNKDL FPSEGSIGIN YGWTGDVKYH 

       310        320        330        340        350        360 
LGADRQIRDE NTAEARLTLA NNPSHLEFVS PIVEGYARAA QEDRTSPGAP EQDIMKAYSI 

       370        380        390        400        410        420 
LIHGDAAFPG QGVVTETLNL SRLTGYQTGG SLHIIANNNI GFTTETFDSR STLYSSDPAK 

       430        440        450        460        470        480 
GFEIPIVHVN ADDPEACLAA VHLAFQYRKR FKKDFLIDLI GYRRFGHNEM DEPAVTQPGV 

       490        500        510        520        530        540 
YQIIRKHPTV RELYSKQLVK KGLIDEQTVK QLDDEVQDKL QSVYEETLRN RTDEHLPDTP 

       550        560        570        580        590        600 
PVEVVNGLPK LDTGVQSETL KAINNELLEW PESFSVNPKL EKILKRRLNV FDGDGKVDWA 

       610        620        630        640        650        660 
LAETLAFATI LHDGTPIRLT GQDSERGTFA HRHLVLHDSR TNDVHSPLQS FRHANASFAV 

       670        680        690        700        710        720 
HNSPLSEMAI VGFEYGYNVF APETLVLWEA QFGDFANGAQ VMFDQWVSAG RAKWGQKSGL 

       730        740        750        760        770        780 
VCLLPHGYEG QGPEHSSARL ERFLVLAAEN NWTIANCTSA AQYFHILRRQ AAILNTDSVR 

       790        800        810        820        830        840 
PLIMMTPKSL LRNQKVASSV EELTTGRFKT VLEQPNLGES HEKVERIVLC SGKIAIDLQD 

       850        860        870        880        890        900 
RIEKEADKDW DWVHIVRVEQ LYPFPKEPLQ EIFARYPNVK EIVWSQEEPR NMGAWPFVQS 

       910        920        930        940 
KIRRAAPNGI NVRYEGRTYR SSPAEGDPII HKQEQERIVT ETLTR 

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000004 Genomic DNA. Translation: BAB05925.1.
PIRF83925.
RefSeqNP_243072.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9KAT1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272558.BH2206.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB05925; BAB05925; BAB05925.
GeneID891738.
KEGGbha:BH2206.
PATRIC18941582. VBIBacHal18977_2304.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0567.
HOGENOMHOG000259588.
KOK00164.
OMAMLSGTHF.
OrthoDBEOG6V1M1F.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-2290-MONOMER.

Family and domain databases

Gene3D3.40.50.970. 2 hits.
HAMAPMF_01169. SucA_OdhA.
InterProIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERPTHR23152. PTHR23152. 1 hit.
PfamPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52518. SSF52518. 2 hits.
TIGRFAMsTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetSearch...

Entry information

Entry nameODO1_BACHD
AccessionPrimary (citable) accession number: Q9KAT1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families