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Q9KAT1

- ODO1_BACHD

UniProt

Q9KAT1 - ODO1_BACHD

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Protein
2-oxoglutarate dehydrogenase E1 component
Gene
odhA, BH2206
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2290-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:BH2206
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9459452-oxoglutarate dehydrogenase E1 componentUniRule annotation
PRO_0000162165Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2206.

Structurei

3D structure databases

ProteinModelPortaliQ9KAT1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiMLSGTHF.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KAT1-1 [UniParc]FASTAAdd to Basket

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MSSKEHTSEE PWQGFYGPNL GVAVELYEEY QKDPNAVDDE LREAFEKWGP    50
PPATAPERTQ STFTAASITD PDVIKKFVGA VKLADHIRAF GHLAADIQPI 100
LKEQRREDMF DLDRFGLTES DIRSVPVDLL CPYAPAHVKN GLDAINHLKE 150
VYTKTIAFEF VHVTDEEERK WLNRMIESGL YLPNLSTEQR KSLLKRLTDV 200
EGFEKFLHRT FVGQKRFSIE GLDTLVPMLD EVVREAVHEG TTNVMIGMAH 250
RGRLNVLAHV LNKPYEMIFA EFLHSLNKDL FPSEGSIGIN YGWTGDVKYH 300
LGADRQIRDE NTAEARLTLA NNPSHLEFVS PIVEGYARAA QEDRTSPGAP 350
EQDIMKAYSI LIHGDAAFPG QGVVTETLNL SRLTGYQTGG SLHIIANNNI 400
GFTTETFDSR STLYSSDPAK GFEIPIVHVN ADDPEACLAA VHLAFQYRKR 450
FKKDFLIDLI GYRRFGHNEM DEPAVTQPGV YQIIRKHPTV RELYSKQLVK 500
KGLIDEQTVK QLDDEVQDKL QSVYEETLRN RTDEHLPDTP PVEVVNGLPK 550
LDTGVQSETL KAINNELLEW PESFSVNPKL EKILKRRLNV FDGDGKVDWA 600
LAETLAFATI LHDGTPIRLT GQDSERGTFA HRHLVLHDSR TNDVHSPLQS 650
FRHANASFAV HNSPLSEMAI VGFEYGYNVF APETLVLWEA QFGDFANGAQ 700
VMFDQWVSAG RAKWGQKSGL VCLLPHGYEG QGPEHSSARL ERFLVLAAEN 750
NWTIANCTSA AQYFHILRRQ AAILNTDSVR PLIMMTPKSL LRNQKVASSV 800
EELTTGRFKT VLEQPNLGES HEKVERIVLC SGKIAIDLQD RIEKEADKDW 850
DWVHIVRVEQ LYPFPKEPLQ EIFARYPNVK EIVWSQEEPR NMGAWPFVQS 900
KIRRAAPNGI NVRYEGRTYR SSPAEGDPII HKQEQERIVT ETLTR 945
Length:945
Mass (Da):106,970
Last modified:October 1, 2000 - v1
Checksum:iDF3D694B15EEAA5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB05925.1.
PIRiF83925.
RefSeqiNP_243072.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB05925; BAB05925; BAB05925.
GeneIDi891738.
KEGGibha:BH2206.
PATRICi18941582. VBIBacHal18977_2304.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB05925.1 .
PIRi F83925.
RefSeqi NP_243072.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9KAT1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272558.BH2206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB05925 ; BAB05925 ; BAB05925 .
GeneIDi 891738.
KEGGi bha:BH2206.
PATRICi 18941582. VBIBacHal18977_2304.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi MLSGTHF.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci BHAL272558:GJC5-2290-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiODO1_BACHD
AccessioniPrimary (citable) accession number: Q9KAT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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