Reviewed, UniProtKB/Swiss-Prot Q9KAN8 (MSRA_BACHD)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrA
      Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
      Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	BH2249

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	176 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity.
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 176	176	Peptide methionine sulfoxide reductase msrA HAMAP MF_01401		PRO_0000138529
Sites
	Active site	14	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9KAN8-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: E772E223E983DFF3	FASTA	176	20,547
	10 20 30 40 50 60 MEKRLERAMF AGGCFWCMVQ PFDKQPGIES VVSGYAGGTV ENPTYEQVKT GTTGHYEVVH 70 80 90 100 110 120 ITYVPELFPF EKLLSLYWPQ IDPTDPDGQF HDRGPQYRTA IFYENEEQRA LAERSREALE 130 140 150 160 170 KSGKFKKPIV TSILPMATFY PAEEEHQQFY KKNPMAYKED REKSGRDEFI YKHWGK

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000004 Genomic DNA. Translation: BAB05968.1.
PIR	A83931.
RefSeq	NP_243115.1.
3D structure databases
HSSP	HSSP built from PDB template 1FVG based on UniProtKB P54149.
ModBase	Search...
Genome annotation databases
GeneID	892349.
GenomeReviews	Gene locus BH2249 in contig BA000004_GR.
KEGG	bha:BH2249.
NMPDR	fig|272558.1.peg.2249.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9KAN8.
OMA	HKGHQEA.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2249-MON.
BRENDA	1.8.4.11. 191865.
Family and domain databases
HAMAP	MF_01401. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
ProDom	PD003489. PMSR. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00401. msrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_BACHD

Accession

Primary (citable) accession number: Q9KAN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	October 1, 2000
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)