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Q9KAH8

- ALLB_BACHD

UniProt

Q9KAH8 - ALLB_BACHD

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Protein
Allantoinase
Gene
allB, pucH, BH2309
Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring By similarity.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Binds 2 zinc ions per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi63 – 631Zinc 1 By similarity
Metal bindingi65 – 651Zinc 1 By similarity
Metal bindingi150 – 1501Zinc 1; via carbamate group By similarity
Metal bindingi150 – 1501Zinc 2; via carbamate group By similarity
Metal bindingi186 – 1861Zinc 2 By similarity
Metal bindingi242 – 2421Zinc 2 By similarity
Metal bindingi315 – 3151Zinc 1 By similarity

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2393-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoinase (EC:3.5.2.5)
Alternative name(s):
Allantoin-utilizing enzyme
Gene namesi
Name:allB
Synonyms:pucH
Ordered Locus Names:BH2309
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438AllantoinaseUniRule annotation
PRO_0000317670Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei150 – 1501N6-carboxylysine By similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions By similarity.UniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2309.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 1410
Beta strandi19 – 279
Beta strandi30 – 367
Beta strandi47 – 493
Beta strandi54 – 574
Beta strandi59 – 646
Turni68 – 703
Helixi72 – 743
Helixi78 – 858
Turni86 – 883
Beta strandi89 – 946
Beta strandi96 – 1016
Helixi106 – 1138
Helixi115 – 1195
Beta strandi121 – 1299
Helixi135 – 1373
Helixi138 – 1436
Beta strandi147 – 1559
Beta strandi157 – 1615
Helixi166 – 17914
Beta strandi183 – 1864
Helixi190 – 20213
Helixi208 – 2147
Helixi217 – 23418
Beta strandi238 – 2403
Helixi246 – 25712
Beta strandi262 – 2665
Helixi268 – 2725
Helixi275 – 2817
Helixi294 – 30613
Helixi321 – 3244
Turni329 – 3313
Turni339 – 3413
Helixi342 – 3498
Turni350 – 3545
Helixi358 – 3658
Helixi367 – 3737
Turni376 – 3783
Beta strandi390 – 40011
Helixi403 – 4053
Beta strandi408 – 4103
Turni414 – 4174
Beta strandi419 – 42911
Beta strandi432 – 4365

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HM7X-ray2.60A/B/C/D/E/F2-438[»]
ProteinModelPortaliQ9KAH8.

Miscellaneous databases

EvolutionaryTraceiQ9KAH8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
KOiK01466.
OMAiCSPWEGH.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KAH8-1 [UniParc]FASTAAdd to Basket

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MKRFDLIIRS STVVTETTTY RADVAIRNGI VSAITEPGSI SSDDGPAIDG    50
TGLHLFPGMV DVHVHFNEPG RTEWEGFASG SKSLAAGGVT TYFDMPLNSN 100
PPTITREELD KKRQLANEKS LVDYRFWGGL VPGNIDHLQD LHDGGVIGFK 150
AFMSECGTDD FQFSHDETLL KGMKKIAALG SILAVHAESN EMVNALTTIA 200
IEEQRLTVKD YSEARPIVSE LEAVERILRF AQLTCCPIHI CHVSSRKVLK 250
RIKQAKGEGV NVSVETCPHY LLFSLDEFAE IGYLAKCAPP LRERQEVEDL 300
WDGLMAGEID LISSDHSPSL PQMKTGKTIF EVWGGIAGCQ NTLAVMLTEG 350
YHKRKMPLTQ IVQLLSTEPA KRFGLYPQKG TIQVGAEASF TLIDLNESYT 400
LNASDLYYRH PISPYVGQRF RGKVKHTICQ GKHVYQDH 438
Length:438
Mass (Da):48,542
Last modified:October 1, 2000 - v1
Checksum:i47A24DD790AF947F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06028.1.
PIRiE83938.
RefSeqiNP_243175.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06028; BAB06028; BAB06028.
GeneIDi892154.
KEGGibha:BH2309.
PATRICi18941796. VBIBacHal18977_2411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06028.1 .
PIRi E83938.
RefSeqi NP_243175.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HM7 X-ray 2.60 A/B/C/D/E/F 2-438 [» ]
ProteinModelPortali Q9KAH8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272558.BH2309.

Protocols and materials databases

DNASUi 892154.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB06028 ; BAB06028 ; BAB06028 .
GeneIDi 892154.
KEGGi bha:BH2309.
PATRICi 18941796. VBIBacHal18977_2411.

Phylogenomic databases

eggNOGi COG0044.
HOGENOMi HOG000219146.
KOi K01466.
OMAi CSPWEGH.
OrthoDBi EOG6KHFW6.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .
BioCyci BHAL272558:GJC5-2393-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9KAH8.

Family and domain databases

Gene3Di 2.30.40.10. 1 hit.
HAMAPi MF_01645. Hydantoinase.
InterProi IPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 2 hits.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiALLB_BACHD
AccessioniPrimary (citable) accession number: Q9KAH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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