Q9KAH1 (IOLG_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
EC=1.1.1.18
EC=1.1.1.n6

Alternative name(s):
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase

Gene names

Name:	iolG
Ordered Locus Names:	BH2316

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity. HAMAP MF_01671
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity. HAMAP MF_01671
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 348	348	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671		PRO_0000352556

Sequences

	Sequence		Length	Mass (Da)
	Q9KAH1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 50EE88A0BEA9E5C8	FASTA	348	38,788
	10 20 30 40 50 60 MTLRFGVIGT GAIGREHMKR IENKLSGGKI VAVTDMNQEA AKQVVTQMKL EADVYPDDRS 70 80 90 100 110 120 LVAADNVDAV LVTSWGPAHE ANVLAAIEAG KYVFVEKPLA TTAEGCMKII KAEMNHGKRL 130 140 150 160 170 180 VQVGFMRRYD KGYVQLKKAI DDHFIGEPLM VRCAHRNPEV GESYIDDMAI HDTLIHEIDV 190 200 210 220 230 240 LHWLIDDEYE SVSVSFPKKT KHALPHLRDP RVVTLETKGG VLITAEVFVN CKYGYDIQCE 250 260 270 280 290 300 VIREEGIASL PEVDSISFRK RATLGTNILM DWKQRFIEAY DVELQHFIDS IKQSGEPSGP 310 320 330 340 NAWDGYVAAI TADAALKASN SGQKQFISLK EKPAFYSVKK ENAHEAML

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06035.1.
PIR	D83939.
RefSeq	NP_243182.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9KAH1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000053508; EBBACP00000052147; EBBACG00000053499.
GeneID	891847.
GenomeReviews	Gene locus BH2316 in contig BA000004_GR.
KEGG	bha:BH2316.
NMPDR	fig|272558.1.peg.2316.
PATRIC	18941810. VBIBacHal18977_2418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000000829.
HOGENOM	HBG612336.
OMA	YDVELQD.
ProtClustDB	CLSK873287.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2316-MONOMER.
Family and domain databases
HAMAP	MF_01671. IolG. [Tree]
InterPro	IPR023794. MI/DCI_dehydrogenase. IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00010.
PANTHER	PTHR22604:SF7. PTHR22604:SF7. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_BACHD

Accession

Primary (citable) accession number: Q9KAH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program