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Protein

5-dehydro-2-deoxygluconokinase

Gene

iolC

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP).UniRule annotation

Catalytic activityi

ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate.UniRule annotation

Pathwayi: myo-inositol degradation into acetyl-CoA

This protein is involved in step 5 of the subpathway that synthesizes acetyl-CoA from myo-inositol.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase (iolG)
  2. Inosose dehydratase (iolE)
  3. 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase (iolD)
  4. 5-deoxy-glucuronate isomerase (iolB)
  5. 5-dehydro-2-deoxygluconokinase (iolC)
  6. 6-phospho-5-dehydro-2-deoxy-D-gluconate aldolase (iolJ)
  7. Methylmalonate semialdehyde dehydrogenase [acylating] (iolA)
This subpathway is part of the pathway myo-inositol degradation into acetyl-CoA, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from myo-inositol, the pathway myo-inositol degradation into acetyl-CoA and in Polyol metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2403-MONOMER.
UniPathwayiUPA00076; UER00146.

Names & Taxonomyi

Protein namesi
Recommended name:
5-dehydro-2-deoxygluconokinaseUniRule annotation (EC:2.7.1.92UniRule annotation)
Alternative name(s):
2-deoxy-5-keto-D-gluconate kinaseUniRule annotation
Short name:
DKG kinaseUniRule annotation
Gene namesi
Name:iolCUniRule annotation
Ordered Locus Names:BH2319
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3313315-dehydro-2-deoxygluconokinasePRO_0000352289Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH2319.

Structurei

Secondary structure

1
331
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 178Combined sources
Beta strandi20 – 278Combined sources
Helixi32 – 343Combined sources
Beta strandi38 – 447Combined sources
Helixi45 – 5511Combined sources
Beta strandi60 – 667Combined sources
Helixi70 – 8112Combined sources
Beta strandi89 – 913Combined sources
Beta strandi100 – 1078Combined sources
Beta strandi110 – 1167Combined sources
Helixi121 – 1244Combined sources
Helixi127 – 1293Combined sources
Helixi132 – 1354Combined sources
Beta strandi138 – 1447Combined sources
Helixi145 – 1484Combined sources
Helixi153 – 16614Combined sources
Beta strandi170 – 1745Combined sources
Helixi179 – 1813Combined sources
Helixi185 – 19814Combined sources
Beta strandi200 – 2056Combined sources
Helixi206 – 2127Combined sources
Helixi221 – 2288Combined sources
Beta strandi234 – 2396Combined sources
Helixi241 – 2433Combined sources
Beta strandi245 – 2495Combined sources
Beta strandi254 – 2574Combined sources
Helixi270 – 28314Combined sources
Helixi288 – 30417Combined sources
Helixi315 – 32410Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QCVX-ray1.90A1-331[»]
ProteinModelPortaliQ9KAG8.
SMRiQ9KAG8. Positions 2-331.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KAG8.

Family & Domainsi

Sequence similaritiesi

Belongs to the carbohydrate kinase PfkB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EDK. Bacteria.
COG0524. LUCA.
HOGENOMiHOG000235951.
KOiK03338.
OMAiDQDGHKA.
OrthoDBiPOG091H0FAQ.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01668. IolC. 1 hit.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR022841. DKG_kinase_firmi.
IPR030830. Myo_inos_iolC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR04382. myo_inos_iolC_N. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KAG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTYELSTDRE FDLIAIGRAC IDLNAVEYNR PMEETMTFSK YVGGSPANIV
60 70 80 90 100
IGSSKLGLKA GFIGKIADDQ HGRFIESYMR GVGVDTSNLV VDQEGHKTGL
110 120 130 140 150
AFTEIKSPEE CSILMYRQDV ADLYLSPEEV NEAYIRRSKL LLVSGTALSK
160 170 180 190 200
SPSREAVLKA IRLAKRNDVK VVFELDYRPY SWETPEETAV YYSLVAEQSD
210 220 230 240 250
IVIGTREEFD VLENRTEKGD NDETIRYLFK HSPELIVIKH GVEGSFAYTK
260 270 280 290 300
AGEAYRGYAY KTKVLKTFGA GDSYASAFLY ALISGKGIET ALKYGSASAS
310 320 330
IVVSKHSSSD AMPSVEEIEA LIEKDETITI A
Length:331
Mass (Da):36,641
Last modified:October 1, 2000 - v1
Checksum:iA9C559702FED958E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06038.1.
PIRiG83939.
RefSeqiWP_010898475.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06038; BAB06038; BAB06038.
KEGGibha:BH2319.
PATRICi18941816. VBIBacHal18977_2421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06038.1.
PIRiG83939.
RefSeqiWP_010898475.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QCVX-ray1.90A1-331[»]
ProteinModelPortaliQ9KAG8.
SMRiQ9KAG8. Positions 2-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06038; BAB06038; BAB06038.
KEGGibha:BH2319.
PATRICi18941816. VBIBacHal18977_2421.

Phylogenomic databases

eggNOGiENOG4105EDK. Bacteria.
COG0524. LUCA.
HOGENOMiHOG000235951.
KOiK03338.
OMAiDQDGHKA.
OrthoDBiPOG091H0FAQ.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00146.
BioCyciBHAL272558:GJC5-2403-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9KAG8.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_01668. IolC. 1 hit.
InterProiIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR022841. DKG_kinase_firmi.
IPR030830. Myo_inos_iolC.
IPR011611. PfkB_dom.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF00294. PfkB. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR04382. myo_inos_iolC_N. 1 hit.
PROSITEiPS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIOLC_BACHD
AccessioniPrimary (citable) accession number: Q9KAG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.