Q9KA05 (RNC_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease 3
EC=3.1.26.3

Alternative name(s):
Ribonuclease III
Short name=RNase III

Gene names

Name:	rnc
Synonyms:	rncS
Ordered Locus Names:	BH2489

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity. HAMAP MF_00104
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity HAMAP MF_00104.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	RNA processing Inferred from electronic annotation. Source: InterPro rRNA catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Ribonuclease 3 HAMAP MF_00104		PRO_0000180374
Regions
	Domain	35 – 164	130	RNase III
	Domain	190 – 259	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q9KA05 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 61B8E1C557CC5485	FASTA	263	30,224
	10 20 30 40 50 60 MPHSKNQRKH RHHSHSERRR QPKRLTLTAK QQQMFDELLR TLNLTFANKK LLVQAFTHSS 70 80 90 100 110 120 YVNEHRIQSC KDNERLEFLG DAVLELAVSQ YLYKAFEQMS EGDMTKLRAS IVCEPSLAQL 130 140 150 160 170 180 AEELHFGELV LLGKGEEMTG GRKRPALLAD VFESFVGALY LDQGMDAVYL FLERTIYPKI 190 200 210 220 230 240 SEGAFSHMMD FKSQLQEFIQ RDNLGHIHYE IVQERGPAHN REFVSEVVLN NETLGVGTGR 250 260 SKKEAEQHAA QQALITLSQK KEQ

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06208.1.
PIR	A83961.
RefSeq	NP_243355.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9KA05.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000051768; EBBACP00000050407; EBBACG00000051759.
GeneID	891048.
GenomeReviews	Gene locus BH2489 in contig BA000004_GR.
KEGG	bha:BH2489.
NMPDR	fig|272558.1.peg.2489.
PATRIC	18942168. VBIBacHal18977_2597.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002139.
HOGENOM	HBG744556.
OMA	ALTHKSF.
PhylomeDB	Q9KA05.
ProtClustDB	PRK00102.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2489-MONOMER.
Family and domain databases
HAMAP	MF_00104. RNase_III. [Tree]
InterPro	IPR001159. Ds-RNA-bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
KO	K03685.
PANTHER	PTHR11207. PTHR11207. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
SUPFAM	SSF69065. RNase_III. 1 hit.
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_BACHD

Accession

Primary (citable) accession number: Q9KA05

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program