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Q9KA05 (RNC_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribonuclease 3
EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Synonyms:rncS
Ordered Locus Names:BH2489
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000180374

Regions

Domain35 – 164130RNase III
Domain190 – 25970DRBM

Sites

Active site811 Potential
Active site1531 By similarity
Metal binding771Magnesium By similarity
Metal binding1501Magnesium By similarity
Metal binding1531Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KA05 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 61B8E1C557CC5485

FASTA26330,224
        10         20         30         40         50         60 
MPHSKNQRKH RHHSHSERRR QPKRLTLTAK QQQMFDELLR TLNLTFANKK LLVQAFTHSS 

        70         80         90        100        110        120 
YVNEHRIQSC KDNERLEFLG DAVLELAVSQ YLYKAFEQMS EGDMTKLRAS IVCEPSLAQL 

       130        140        150        160        170        180 
AEELHFGELV LLGKGEEMTG GRKRPALLAD VFESFVGALY LDQGMDAVYL FLERTIYPKI 

       190        200        210        220        230        240 
SEGAFSHMMD FKSQLQEFIQ RDNLGHIHYE IVQERGPAHN REFVSEVVLN NETLGVGTGR 

       250        260 
SKKEAEQHAA QQALITLSQK KEQ

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB06208.1.
PIRA83961.
RefSeqNP_243355.1. NC_002570.2.

3D structure databases

ProteinModelPortalQ9KA05.
ModBaseSearch...

Protein-protein interaction databases

STRING272558.BH2489.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB06208; BAB06208; BAB06208.
GeneID891048.
KEGGbha:BH2489.
PATRIC18942168. VBIBacHal18977_2597.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMALTHKSCK.
ProtClustDBPRK00102.

Enzyme and pathway databases

BioCycBHAL272558:GJC5-2573-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR001159. Ds-RNA-bd.
IPR014720. dsRNA-bd-like_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF00636. Ribonuclease_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. RNase_III. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS00517. RNASE_3_1. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_BACHD
AccessionPrimary (citable) accession number: Q9KA05
Entry history
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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