Q9K9W3 (PYRE_BACHD)
Reviewed,
UniProtKB/Swiss-Prot
Last modified
August 10, 2010.
Version 58.
History...
Names and origin
| Protein names | Recommended name: Orotate phosphoribosyltransferase Short name=OPRT Short name=OPRTase EC=2.4.2.10 | ||||
| Gene names |
| ||||
| Organism | Bacillus halodurans [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 86665 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus |
Protein attributes
| Sequence length | 210 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208_B |
| Catalytic activity | Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208_B |
| Cofactor | Magnesium By similarity. HAMAP MF_01208_B |
| Pathway | Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208_B |
| Subunit structure | Homodimer By similarity. HAMAP MF_01208_B |
| Sequence similarities | Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyrimidine biosynthesis |
| Ligand | Magnesium |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | orotate phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 210 | 210 | Orotate phosphoribosyltransferase HAMAP MF_01208_B | PRO_0000110670 | |||||
Regions | |||||||||
| Region | 120 – 128 | 9 | 5-phosphoribose 1-diphosphate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 94 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 98 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 100 | 1 | 5-phosphoribose 1-diphosphate; shared with dimeric partner By similarity | ||||||
| Binding site | 124 | 1 | Orotate By similarity | ||||||
Sequences
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References
| [1] | "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BA000004 Genomic DNA. Translation: BAB06251.1. |
| PIR | D83966. |
| RefSeq | NP_243398.1. |
3D structure databases | |
| ProteinModelPortal | Q9K9W3. |
| SMR | Q9K9W3. Positions 1-204. |
| ModBase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBBACT00000050764; EBBACP00000049403; EBBACG00000050755. |
| GeneID | 891489. |
| GenomeReviews | Gene locus BH2532 in contig BA000004_GR. |
| KEGG | bha:BH2532. |
| NMPDR | fig|272558.1.peg.2532. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG404341. |
| OMA | LPMTYVR. |
| ProtClustDB | PRK00455. |
Enzyme and pathway databases | |
| BioCyc | BHAL272558:BH2532-MONOMER. |
| BRENDA | 2.4.2.10. 191865. |
Family and domain databases | |
| HAMAP | MF_01208_B. PyrE_B. [Tree] |
| InterPro | IPR004467. Or_phspho_trans. IPR000836. PRibTrfase. [Graphical view] |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00336. pyrE. 1 hit. |
| PROSITE | PS00103. PUR_PYR_PR_TRANSFER. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PYRE_BACHD | ||||||||
| Accession | Primary (citable) accession number: Q9K9W3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


