Reviewed, UniProtKB/Swiss-Prot Q9K9V6 (PYRB_BACHD)

Names and origin

Protein names

Recommended name:
    Aspartate carbamoyltransferase
    EC=2.1.3.2
Alternative name(s):
    Aspartate transcarbamylase
      Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	BH2539

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	305 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 305	305	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113095

Sequences

	Sequence		Length	Mass (Da)
	Q9K9V6-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 974D09A8D5410074	FASTA	305	34,829
	10 20 30 40 50 60 MAVPFLQDHD TKHDLLTMSH LSLEEIEHIL HDAQQFENGA LWSPEEKLFV ANLFFEPSTR 70 80 90 100 110 120 TRVSFEVAEQ RLGLHVVNVD GERSSVQKGE TLYDTAKTLE SIGVNALVIR HRQDRYFEEL 130 140 150 160 170 180 KDRINIPIIN AGDGCGHHPT QSLLDLWTIQ QEFGRFSNLI TVISGDLRHS RVARSNAETL 190 200 210 220 230 240 TRLGARVYIS GPREWMEGYE GVYPYVTMDE AVELADVIML LRVQHERHDG TVSFTQASYH 250 260 270 280 290 300 EQFGLTVKRE ARMKPKSIVM HPAPVNRNVE IASELVECPR SRIFKQMKNG VAIRMAVLKR ALTDE

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06258.1.
PIR	C83967.
RefSeq	NP_243405.1.
3D structure databases
SMR	Q9K9V6. Positions 12-302.
ModBase	Search...
Genome annotation databases
GeneID	891505.
GenomeReviews	Gene locus BH2539 in contig BA000004_GR.
KEGG	bha:BH2539.
NMPDR	fig|272558.1.peg.2539.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	HANIINA.
PhylomeDB	Q9K9V6.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2539-MONOMER.
BRENDA	2.1.3.2. 191865.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
TIGRFAMs	TIGR00670. asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_BACHD

Accession

Primary (citable) accession number: Q9K9V6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)