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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:BH2568/BH2569
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalUniRule annotationAdd BLAST21
Transmembranei57 – 77HelicalUniRule annotationAdd BLAST21
Transmembranei81 – 101HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21
Transmembranei252 – 272HelicalUniRule annotationAdd BLAST21
Transmembranei304 – 324HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001087791 – 325Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST325

Interactioni

Protein-protein interaction databases

STRINGi272558.BH2568

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0472 LUCA
KOiK01000
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K9S6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERVLLLTL ILSFVITVIL SPIFIPFLRR LKFGQSIREE GPKSHQKKSG
60 70 80 90 100
TPTMGGLMIL LSILVSSLFV SFQLSIFSMD VLLLLLVTIG FGVLGFIDDF
110 120 130 140 150
IKVVMKRNLG LTSKQKLIGQ LVVAVLFYLG LRNMGLSTEV TIPATSLSID
160 170 180 190 200
FGWFYLPLVI VMLVGASNAV NLTDGLDGLV AGTGAIAFGA FAIIAWATNY
210 220 230 240 250
FEVAIFSAAV VGAVLGFLVF NSHPAKVFMG DTGSLALGGA IAAIAIMAKQ
260 270 280 290 300
EILLIIIGGV FVIETLSVII QVISFKTRGK RIFKMSPLHH HYELSGWSEW
310 320
RVVVTFWTVG LLFAMLAIYL EVWIT
Length:325
Mass (Da):35,377
Last modified:April 23, 2003 - v2
Checksum:iC23434161DA41B8A
GO

Sequence cautioni

The sequence BAB06288 differs from that shown. Reason: Frameshift at position 78. Produces two separate ORFs.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB06287.1 Frameshift.
BA000004 Genomic DNA Translation: BAB06288.1 Frameshift.
PIRiA83971
H83970

Genome annotation databases

EnsemblBacteriaiBAB06287; BAB06287; BAB06287
BAB06288; BAB06288; BAB06288
KEGGibha:BH2568
bha:BH2569

Similar proteinsi

Entry informationi

Entry nameiMRAY_BACHD
AccessioniPrimary (citable) accession number: Q9K9S6
Secondary accession number(s): Q9K9S7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: April 25, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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