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Protein

Glutaminase 1

Gene

glsA1

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei64 – 641SubstrateUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei161 – 1611SubstrateUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Binding sitei192 – 1921SubstrateUniRule annotation
Binding sitei244 – 2441SubstrateUniRule annotation
Binding sitei262 – 2621Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2711-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 1UniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsA1UniRule annotation
Ordered Locus Names:BH2627
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Glutaminase 1PRO_0000110592Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2627.

Structurei

3D structure databases

ProteinModelPortaliQ9K9L8.
SMRiQ9K9L8. Positions 6-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKQDETLEQ IVLECKKYTE EGTVASYIPA LAKADVSTLG IAIYRGGDEQ
60 70 80 90 100
VIAGDADEKF TLQSISKVIA LALALLDVGE EAVFSKVGME PTGDPFNSIS
110 120 130 140 150
KLETSVPSKP LNPMINAGAL AVTNMIIGET TEQSLGRLLS FIHELTKNPT
160 170 180 190 200
ITYNLEVAQS EFDTAFLNRS LSYFLKQHGV IQADVEQLLD LYTKQCAIEM
210 220 230 240 250
CCSDLARIGY VFANEGRDPD TGQRIVPLHV ARIIKTFMVT CGMYNASGEF
260 270 280 290 300
AIRVGIPAKS GVSGAILALV PNKYGIAVYS PALDEKGNSL AGIKLLETLS

CREEWSIF
Length:308
Mass (Da):33,456
Last modified:October 1, 2000 - v1
Checksum:iB8D3F17E16514590
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06346.1.
PIRiC83978.
RefSeqiNP_243493.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06346; BAB06346; BAB06346.
KEGGibha:BH2627.
PATRICi18942442. VBIBacHal18977_2734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06346.1.
PIRiC83978.
RefSeqiNP_243493.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K9L8.
SMRiQ9K9L8. Positions 6-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2627.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06346; BAB06346; BAB06346.
KEGGibha:BH2627.
PATRICi18942442. VBIBacHal18977_2734.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiTKQCAIE.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2711-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiGLSA1_BACHD
AccessioniPrimary (citable) accession number: Q9K9L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.