Q9K9K5 (SPEA_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine decarboxylase
EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	BH2640

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of agmatine from arginine By similarity.
Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-I family.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Arginine decarboxylase		PRO_0000201146
Amino acid modifications
	Modified residue	227	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9K9K5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 3C2ACC55C3C57F5D	FASTA	491	53,449
	10 20 30 40 50 60 MSRQEQTPLF SGVVAHAKHN PVQFHIPGHK KGAGMDPAFR SFIGDNALSI DLINIGPLDD 70 80 90 100 110 120 LHHPHGIIKE AQELAAEAFG ADHTFFSVQG TSGAIMTMIM SVVGPGEKII VPRNVHKSIM 130 140 150 160 170 180 SAIVFSGATP VFIHPEIDPL LGISHGITIE AVEKALDAHP DAKGLLVINP TYFGIAANLK 190 200 210 220 230 240 KIVELCHSRD VPVLVDEAHG VHIHFHEALP LSAMQAGADM AATSVHKLGG SLTQSSILNV 250 260 270 280 290 300 REGLVSAKRV QTIISMLTTT STSYLLLASL DAARKHLATN GRDLIGYTIQ LADQARDQIN 310 320 330 340 350 360 AIDGLYCVGK EILGTIATYD YDPTKLIISV KNLGITGYDA EVWLREHYQI EVELSDLYNI 370 380 390 400 410 420 LCIVSFGDTE REMDLLVKAL SELADLHKHG ICERSPVSVY VPNIPTLAMS PRDAFYAETE 430 440 450 460 470 480 VVPFEDSVGR TIAEFIMVYP PGIPILIPGE IITESNLAYI RENNRAGLPV QGPEDDTFRT 490 LRVIKEHEAI R

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06359.1.
PIR	H83979.
RefSeq	NP_243506.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9K9K5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000053887; EBBACP00000052526; EBBACG00000053878.
GeneID	892594.
GenomeReviews	Gene locus BH2640 in contig BA000004_GR.
KEGG	bha:BH2640.
NMPDR	fig|272558.1.peg.2640.
PATRIC	18942470. VBIBacHal18977_2748.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002042.
HOGENOM	HBG634412.
OMA	MEYVNRK.
PhylomeDB	Q9K9K5.
ProtClustDB	CLSK873379.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2640-MONOMER.
Family and domain databases
InterPro	IPR000310. Orn/Lys/Arg_deCO2ase_major_dom. IPR008286. Prn/Lys/Arg_de-COase_C. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.90.100.10. Decarbxylse_C. 1 hit. G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
KO	K01582.
Pfam	PF01276. OKR_DC_1. 1 hit. PF03711. OKR_DC_1_C. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00703. OKR_DC_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_BACHD

Accession

Primary (citable) accession number: Q9K9K5

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program