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Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pathway: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2724-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BH2640
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Arginine decarboxylasePRO_0000201146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271N6-(pyridoxal phosphate)lysineBy similarity

Interactioni

Protein-protein interaction databases

STRINGi272558.BH2640.

Structurei

3D structure databases

ProteinModelPortaliQ9K9K5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1982.
HOGENOMiHOG000083489.
KOiK01582.
OMAiMEYVNRD.
OrthoDBiEOG61CKX5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K9K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQEQTPLF SGVVAHAKHN PVQFHIPGHK KGAGMDPAFR SFIGDNALSI
60 70 80 90 100
DLINIGPLDD LHHPHGIIKE AQELAAEAFG ADHTFFSVQG TSGAIMTMIM
110 120 130 140 150
SVVGPGEKII VPRNVHKSIM SAIVFSGATP VFIHPEIDPL LGISHGITIE
160 170 180 190 200
AVEKALDAHP DAKGLLVINP TYFGIAANLK KIVELCHSRD VPVLVDEAHG
210 220 230 240 250
VHIHFHEALP LSAMQAGADM AATSVHKLGG SLTQSSILNV REGLVSAKRV
260 270 280 290 300
QTIISMLTTT STSYLLLASL DAARKHLATN GRDLIGYTIQ LADQARDQIN
310 320 330 340 350
AIDGLYCVGK EILGTIATYD YDPTKLIISV KNLGITGYDA EVWLREHYQI
360 370 380 390 400
EVELSDLYNI LCIVSFGDTE REMDLLVKAL SELADLHKHG ICERSPVSVY
410 420 430 440 450
VPNIPTLAMS PRDAFYAETE VVPFEDSVGR TIAEFIMVYP PGIPILIPGE
460 470 480 490
IITESNLAYI RENNRAGLPV QGPEDDTFRT LRVIKEHEAI R
Length:491
Mass (Da):53,449
Last modified:October 1, 2000 - v1
Checksum:i3C2ACC55C3C57F5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06359.1.
PIRiH83979.
RefSeqiNP_243506.1. NC_002570.2.
WP_010898791.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06359; BAB06359; BAB06359.
KEGGibha:BH2640.
PATRICi18942470. VBIBacHal18977_2748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06359.1.
PIRiH83979.
RefSeqiNP_243506.1. NC_002570.2.
WP_010898791.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K9K5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06359; BAB06359; BAB06359.
KEGGibha:BH2640.
PATRICi18942470. VBIBacHal18977_2748.

Phylogenomic databases

eggNOGiCOG1982.
HOGENOMiHOG000083489.
KOiK01582.
OMAiMEYVNRD.
OrthoDBiEOG61CKX5.

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284.
BioCyciBHAL272558:GJC5-2724-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.100.10. 1 hit.
InterProiIPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PfamiPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
SSF55904. SSF55904. 1 hit.
PROSITEiPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiSPEA_BACHD
AccessioniPrimary (citable) accession number: Q9K9K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.