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Protein

Arginine decarboxylase

Gene

speA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of agmatine from arginine.By similarity

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (speA)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPolyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase (EC:4.1.1.19)
Gene namesi
Name:speA
Ordered Locus Names:BH2640
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002011461 – 491Arginine decarboxylaseAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei227N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Protein-protein interaction databases

STRINGi272558.BH2640

Structurei

3D structure databases

ProteinModelPortaliQ9K9K5
SMRiQ9K9K5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXN Bacteria
COG1982 LUCA
HOGENOMiHOG000083489
KOiK01585
OMAiWSTLLTE
OrthoDBiPOG091H01A4

Family and domain databases

CDDicd00615 Orn_deC_like, 1 hit
Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR000310 Orn/Lys/Arg_deCO2ase_major_dom
IPR008286 Prn/Lys/Arg_de-COase_C
IPR036633 Prn/Lys/Arg_de-COase_C_sf
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF01276 OKR_DC_1, 1 hit
PF03711 OKR_DC_1_C, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
SSF55904 SSF55904, 1 hit
PROSITEiView protein in PROSITE
PS00703 OKR_DC_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K9K5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQEQTPLF SGVVAHAKHN PVQFHIPGHK KGAGMDPAFR SFIGDNALSI
60 70 80 90 100
DLINIGPLDD LHHPHGIIKE AQELAAEAFG ADHTFFSVQG TSGAIMTMIM
110 120 130 140 150
SVVGPGEKII VPRNVHKSIM SAIVFSGATP VFIHPEIDPL LGISHGITIE
160 170 180 190 200
AVEKALDAHP DAKGLLVINP TYFGIAANLK KIVELCHSRD VPVLVDEAHG
210 220 230 240 250
VHIHFHEALP LSAMQAGADM AATSVHKLGG SLTQSSILNV REGLVSAKRV
260 270 280 290 300
QTIISMLTTT STSYLLLASL DAARKHLATN GRDLIGYTIQ LADQARDQIN
310 320 330 340 350
AIDGLYCVGK EILGTIATYD YDPTKLIISV KNLGITGYDA EVWLREHYQI
360 370 380 390 400
EVELSDLYNI LCIVSFGDTE REMDLLVKAL SELADLHKHG ICERSPVSVY
410 420 430 440 450
VPNIPTLAMS PRDAFYAETE VVPFEDSVGR TIAEFIMVYP PGIPILIPGE
460 470 480 490
IITESNLAYI RENNRAGLPV QGPEDDTFRT LRVIKEHEAI R
Length:491
Mass (Da):53,449
Last modified:October 1, 2000 - v1
Checksum:i3C2ACC55C3C57F5D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB06359.1
PIRiH83979
RefSeqiWP_010898791.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB06359; BAB06359; BAB06359
KEGGibha:BH2640

Similar proteinsi

Entry informationi

Entry nameiSPEA_BACHD
AccessioniPrimary (citable) accession number: Q9K9K5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health