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Q9K9H0

- ACEA_BACHD

UniProt

Q9K9H0 - ACEA_BACHD

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Protein

Isocitrate lyase

Gene

aceA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).By similarity

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2761-MONOMER.
RETL1328306-WGS:GSTH-727-MONOMER.
UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:aceA
Ordered Locus Names:BH2677
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Isocitrate lyasePRO_0000068771Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi272558.BH2677.

Structurei

3D structure databases

ProteinModelPortaliQ9K9H0.
SMRiQ9K9H0. Positions 3-425.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2224.
HOGENOMiHOG000238475.
KOiK01637.
OMAiDQIQWAN.
OrthoDBiEOG689HMX.

Family and domain databases

Gene3Di3.20.20.60. 1 hit.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K9H0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGWQETAEK LEMSWSNDVR WQGVERPYSG EEVVKLRGSL KIEYTLAKTG
60 70 80 90 100
AEKLWKLLHE EDYVNALGAM TGGQAIQQVK AGLKAIYLSG WQVAADANLA
110 120 130 140 150
GHMYPDQSLY PANSVPSVVK RINQALQRAD QIQHLEGEGE VDYFAPIVAD
160 170 180 190 200
AEAGFGGQLN VFELMKAMIE AGASGVHFED QLASEKKCGH LGGKVLIPTQ
210 220 230 240 250
TAIRNLVSAR LAADVMGVPT ILVARTDADA ADLITSDIDP ADQRFITGER
260 270 280 290 300
TPEGFYRTNA GIEQAIARGL AYAPYADLIW CETSKPSLEE AKQFADAIHE
310 320 330 340 350
KFPGKLLAYN CSPSFNWEAN LDRATIETFQ QELGKMGYKF QFVTLAGFHA
360 370 380 390 400
LNHSMFELAY GYKQRGMGAY SELQQAEFAS EVKGYTATRH QREVGTGYFD
410 420
QVAQTITGGT SSTTALTGST EEAQFQK
Length:427
Mass (Da):46,783
Last modified:October 1, 2000 - v1
Checksum:i0C52D4A9F89E0DFE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06396.1.
PIRiE83984.
RefSeqiNP_243543.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06396; BAB06396; BAB06396.
GeneIDi893670.
KEGGibha:BH2677.
PATRICi18942542. VBIBacHal18977_2784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000004 Genomic DNA. Translation: BAB06396.1 .
PIRi E83984.
RefSeqi NP_243543.1. NC_002570.2.

3D structure databases

ProteinModelPortali Q9K9H0.
SMRi Q9K9H0. Positions 3-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272558.BH2677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB06396 ; BAB06396 ; BAB06396 .
GeneIDi 893670.
KEGGi bha:BH2677.
PATRICi 18942542. VBIBacHal18977_2784.

Phylogenomic databases

eggNOGi COG2224.
HOGENOMi HOG000238475.
KOi K01637.
OMAi DQIQWAN.
OrthoDBi EOG689HMX.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .
BioCyci BHAL272558:GJC5-2761-MONOMER.
RETL1328306-WGS:GSTH-727-MONOMER.

Family and domain databases

Gene3Di 3.20.20.60. 1 hit.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiACEA_BACHD
AccessioniPrimary (citable) accession number: Q9K9H0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3