Q9K9D5 (AROA2_BACHD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase 2
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase 2
Short name=EPSP synthase 2
Short name=EPSPS 2

Gene names

Name:	aroA2
Ordered Locus Names:	BH2713

Organism

Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]

Taxonomic identifier

272558 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	3-phosphoshikimate 1-carboxyvinyltransferase 2 HAMAP MF_00210		PRO_0000088223

Sequences

	Sequence		Length	Mass (Da)
	Q9K9D5 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: C25A5C583D066B00	FASTA	447	48,781
	10 20 30 40 50 60 MTRFDENARS PWTPLHDVKT VELFPLNQRL DGSITLPGSK SLTNRALIIS ALANSDSMLT 70 80 90 100 110 120 GMLKSDDTYW CIQALKRLGV QINVQGETTS IRGIGGQWKS SSLYIGAAGT LARFLLGALA 130 140 150 160 170 180 ISRSGNWEIE ASQSMSKRPI EPLVGVLREL GATIHYLRRE GFYPLSIHGN GLAGGTVRLS 190 200 210 220 230 240 GQMSSQYISG LLIAAPYADT PVTITVQGSI VQHAYVFLTL HLMKSFGAQV EYDQQLQTIV 250 260 270 280 290 300 VHPTPYTCQD IDLEADASTA CYFLALAALT KGRIRLNNLT ASTTQPDLHM LTVFEKMGCT 310 320 330 340 350 360 VTRGSSFIEL EGVSQLKGGF QISMNEMSDQ ALTLAAIAPF ADGPITITDV EHIRYHESDR 370 380 390 400 410 420 IAVICEALTR LGIQVDEFED GLTVYPGTPK PTLHPLSTYD DHRVAMSLSL IGTKVKGLRL 430 440 NDPGCVAKTC PSYFQLLEQL GIQVHYQ

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06432.1.
PIR	A83989.
RefSeq	NP_243579.1. NC_002570.2.
3D structure databases
ProteinModelPortal	Q9K9D5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000050392; EBBACP00000049031; EBBACG00000050383.
GeneID	893562.
GenomeReviews	Gene locus BH2713 in contig BA000004_GR.
KEGG	bha:BH2713.
NMPDR	fig|272558.1.peg.2713.
PATRIC	18942612. VBIBacHal18977_2819.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000001036.
HOGENOM	HBG646626.
OMA	GADIEWG.
PhylomeDB	Q9K9D5.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2713-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. False negative. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA2_BACHD

Accession

Primary (citable) accession number: Q9K9D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program