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Protein

Glutaminase 2

Gene

glsA2

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamine + H2O = L-glutamate + NH3.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei75 – 751SubstrateUniRule annotation
Binding sitei127 – 1271SubstrateUniRule annotation
Binding sitei171 – 1711SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Binding sitei202 – 2021SubstrateUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Binding sitei272 – 2721Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. glutaminase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glutamine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2801-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaminase 2UniRule annotation (EC:3.5.1.2UniRule annotation)
Gene namesi
Name:glsA2UniRule annotation
Ordered Locus Names:BH2717
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Glutaminase 2PRO_0000110593Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2717.

Structurei

3D structure databases

ProteinModelPortaliQ9K9D1.
SMRiQ9K9D1. Positions 28-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiLACEVEE.
OrthoDBiEOG6N94BK.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9K9D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQQKQSLLE HKPVLSKELE KLVNHYRTLS LNGQCAQYIP ALREANQTYL
60 70 80 90 100
GLYVVHSNGI EIKSGDWQVP FTLQSISKII NFIAACLDRG ITYVLDRVDV
110 120 130 140 150
EPTGDPFNSM VRLEMRKTGK PFNPMINAGA ITVASLLSGK SPTEKLESVY
160 170 180 190 200
SLVEKMLGRR ASANEAVFHS EWQTAHRNRS LAYYLKDTGY LESEVDDALH
210 220 230 240 250
VYFTLCAIEV ATKDIAKIGL ILANNGYDPL SHQQIFPKEV AKLTKALMLT
260 270 280 290 300
CGMYNASGTF AAHIGIPAKS GVSGGIMAAV PARGRSDEAM GIGIYGPAID
310 320
DFGNSVAGVA LLKHLSHMWD LSIF
Length:324
Mass (Da):35,506
Last modified:October 1, 2000 - v1
Checksum:i03B9D3F716B01474
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06436.1.
PIRiE83989.
RefSeqiNP_243583.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06436; BAB06436; BAB06436.
KEGGibha:BH2717.
PATRICi18942620. VBIBacHal18977_2823.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06436.1.
PIRiE83989.
RefSeqiNP_243583.1. NC_002570.2.

3D structure databases

ProteinModelPortaliQ9K9D1.
SMRiQ9K9D1. Positions 28-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06436; BAB06436; BAB06436.
KEGGibha:BH2717.
PATRICi18942620. VBIBacHal18977_2823.

Phylogenomic databases

eggNOGiCOG2066.
HOGENOMiHOG000216890.
KOiK01425.
OMAiLACEVEE.
OrthoDBiEOG6N94BK.

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2801-MONOMER.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
HAMAPiMF_00313. Glutaminase.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR015868. Glutaminase.
[Graphical view]
PANTHERiPTHR12544. PTHR12544. 1 hit.
PfamiPF04960. Glutaminase. 1 hit.
[Graphical view]
SUPFAMiSSF56601. SSF56601. 1 hit.
TIGRFAMsiTIGR03814. Gln_ase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiGLSA2_BACHD
AccessioniPrimary (citable) accession number: Q9K9D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 1, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.