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Protein

1-pyrroline-5-carboxylate dehydrogenase 1

Gene

rocA1

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate 5-semialdehyde + NAD+ + H2O = L-glutamate + NADH.

Pathwayi: L-proline degradation into L-glutamate

This protein is involved in step 2 of the subpathway that synthesizes L-glutamate from L-proline.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 1-pyrroline-5-carboxylate dehydrogenase 2 (rocA2), 1-pyrroline-5-carboxylate dehydrogenase 1 (rocA1)
This subpathway is part of the pathway L-proline degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate from L-proline, the pathway L-proline degradation into L-glutamate and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861By similarity
Active sitei320 – 3201By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBHAL272558:GJC5-2822-MONOMER.
UniPathwayiUPA00261; UER00374.

Names & Taxonomyi

Protein namesi
Recommended name:
1-pyrroline-5-carboxylate dehydrogenase 1 (EC:1.2.1.88)
Short name:
P5C dehydrogenase 1
Alternative name(s):
L-glutamate gamma-semialdehyde dehydrogenase
Gene namesi
Name:rocA1
Ordered Locus Names:BH2737
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5155151-pyrroline-5-carboxylate dehydrogenase 1PRO_0000056507Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272558.BH2737.

Structurei

Secondary structure

1
515
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi16 – 3217Combined sources
Beta strandi35 – 373Combined sources
Beta strandi39 – 413Combined sources
Beta strandi44 – 463Combined sources
Beta strandi49 – 557Combined sources
Beta strandi57 – 593Combined sources
Beta strandi63 – 686Combined sources
Helixi72 – 8918Combined sources
Helixi94 – 11017Combined sources
Helixi112 – 12211Combined sources
Helixi127 – 15226Combined sources
Beta strandi163 – 1719Combined sources
Beta strandi174 – 1785Combined sources
Turni182 – 1854Combined sources
Helixi186 – 19712Combined sources
Beta strandi201 – 2055Combined sources
Helixi211 – 22313Combined sources
Beta strandi230 – 2334Combined sources
Turni238 – 2414Combined sources
Helixi242 – 2476Combined sources
Beta strandi251 – 2588Combined sources
Helixi260 – 27011Combined sources
Beta strandi282 – 2865Combined sources
Beta strandi292 – 2954Combined sources
Helixi301 – 31313Combined sources
Helixi314 – 3174Combined sources
Beta strandi325 – 3295Combined sources
Turni330 – 3323Combined sources
Helixi333 – 34412Combined sources
Helixi365 – 38117Combined sources
Beta strandi382 – 3865Combined sources
Beta strandi393 – 3953Combined sources
Beta strandi401 – 4055Combined sources
Helixi411 – 4144Combined sources
Beta strandi419 – 42911Combined sources
Helixi430 – 4389Combined sources
Beta strandi440 – 44910Combined sources
Helixi453 – 46210Combined sources
Beta strandi466 – 4727Combined sources
Turni479 – 4813Combined sources
Turni499 – 5013Combined sources
Helixi502 – 5054Combined sources
Beta strandi506 – 5149Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QANX-ray1.95A/B/C1-515[»]
ProteinModelPortaliQ9K9B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271511.
KOiK00294.
OMAiLAHGNCV.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00733. RocA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9K9B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQPYKHEPF TDFTVEANRK AFEEALGLVE KELGKEYPLI INGERVTTED
60 70 80 90 100
KIQSWNPARK DQLVGSVSKA NQDLAEKAIQ SADEAFQTWR NVNPEERANI
110 120 130 140 150
LVKAAAIIRR RKHEFSAWLV HEAGKPWKEA DADTAEAIDF LEYYARQMIE
160 170 180 190 200
LNRGKEILSR PGEQNRYFYT PMGVTVTISP WNFALAIMVG TAVAPIVTGN
210 220 230 240 250
TVVLKPASTT PVVAAKFVEV LEDAGLPKGV INYVPGSGAE VGDYLVDHPK
260 270 280 290 300
TSLITFTGSK DVGVRLYERA AVVRPGQNHL KRVIVEMGGK DTVVVDRDAD
310 320 330 340 350
LDLAAESILV SAFGFSGQKC SAGSRAVIHK DVYDEVLEKT VALAKNLTVG
360 370 380 390 400
DPTNRDNYMG PVIDEKAFEK IMSYIEIGKK EGRLMTGGEG DSSTGFFIQP
410 420 430 440 450
TIIADLDPEA VIMQEEIFGP VVAFSKANDF DHALEIANNT EYGLTGAVIT
460 470 480 490 500
RNRAHIEQAK REFHVGNLYF NRNCTGAIVG YHPFGGFKMS GTDSKAGGPD
510
YLALHMQAKT VSEMY
Length:515
Mass (Da):56,642
Last modified:October 1, 2000 - v1
Checksum:i1AA5F76CA3093749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06456.1.
PIRiA83992.
RefSeqiWP_010898885.1. NC_002570.2.

Genome annotation databases

EnsemblBacteriaiBAB06456; BAB06456; BAB06456.
KEGGibha:BH2737.
PATRICi18942658. VBIBacHal18977_2841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA. Translation: BAB06456.1.
PIRiA83992.
RefSeqiWP_010898885.1. NC_002570.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3QANX-ray1.95A/B/C1-515[»]
ProteinModelPortaliQ9K9B2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272558.BH2737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB06456; BAB06456; BAB06456.
KEGGibha:BH2737.
PATRICi18942658. VBIBacHal18977_2841.

Phylogenomic databases

eggNOGiENOG4105C26. Bacteria.
COG1012. LUCA.
HOGENOMiHOG000271511.
KOiK00294.
OMAiLAHGNCV.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00261; UER00374.
BioCyciBHAL272558:GJC5-2822-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_00733. RocA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. RocA.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
    Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
    Nucleic Acids Res. 28:4317-4331(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.

Entry informationi

Entry nameiROCA1_BACHD
AccessioniPrimary (citable) accession number: Q9K9B2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: January 20, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.