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Q9K9B2 (ROCA1_BACHD) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-pyrroline-5-carboxylate dehydrogenase 1
Short name=P5C dehydrogenase 1
EC=1.5.1.12
Gene names
Name:rocA1
Ordered Locus Names:BH2737
OrganismBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) [Complete proteome] [HAMAP]
Taxonomic identifier272558 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

(S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733

Sequence similarities

Belongs to the aldehyde dehydrogenase family. RocA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 5155151-pyrroline-5-carboxylate dehydrogenase 1 HAMAP MF_00733
PRO_0000056507

Sites

Active site2861 By similarity
Active site3201 By similarity

Secondary structure

1 ............................................................... 515
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9K9B2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1AA5F76CA3093749

FASTA51556,642
        10         20         30         40         50         60 
MLQPYKHEPF TDFTVEANRK AFEEALGLVE KELGKEYPLI INGERVTTED KIQSWNPARK 

        70         80         90        100        110        120 
DQLVGSVSKA NQDLAEKAIQ SADEAFQTWR NVNPEERANI LVKAAAIIRR RKHEFSAWLV 

       130        140        150        160        170        180 
HEAGKPWKEA DADTAEAIDF LEYYARQMIE LNRGKEILSR PGEQNRYFYT PMGVTVTISP 

       190        200        210        220        230        240 
WNFALAIMVG TAVAPIVTGN TVVLKPASTT PVVAAKFVEV LEDAGLPKGV INYVPGSGAE 

       250        260        270        280        290        300 
VGDYLVDHPK TSLITFTGSK DVGVRLYERA AVVRPGQNHL KRVIVEMGGK DTVVVDRDAD 

       310        320        330        340        350        360 
LDLAAESILV SAFGFSGQKC SAGSRAVIHK DVYDEVLEKT VALAKNLTVG DPTNRDNYMG 

       370        380        390        400        410        420 
PVIDEKAFEK IMSYIEIGKK EGRLMTGGEG DSSTGFFIQP TIIADLDPEA VIMQEEIFGP 

       430        440        450        460        470        480 
VVAFSKANDF DHALEIANNT EYGLTGAVIT RNRAHIEQAK REFHVGNLYF NRNCTGAIVG 

       490        500        510 
YHPFGGFKMS GTDSKAGGPD YLALHMQAKT VSEMY

« Hide

References

[1]"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis."
Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.
Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000004 Genomic DNA. Translation: BAB06456.1.
PIRA83992.
RefSeqNP_243603.1. NC_002570.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3QANX-ray1.95A/B/C1-515[»]
ProteinModelPortalQ9K9B2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000053814; EBBACP00000052453; EBBACG00000053805.
GeneID893516.
GenomeReviewsGene locus BH2737 in contig BA000004_GR.
KEGGbha:BH2737.
NMPDRfig|272558.1.peg.2737.
PATRIC18942658. VBIBacHal18977_2841.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00070000031871.
HOGENOMHBG752218.
OMAWLKRTIL.
PhylomeDBQ9K9B2.
ProtClustDBPRK03137.

Enzyme and pathway databases

BioCycBHAL272558:BH2737-MONOMER.

Family and domain databases

HAMAPMF_00733. RocA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR005932. Delta1-pyrroline-5-COlate_DH-2.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK00294.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01237. D1pyr5carbox2. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameROCA1_BACHD
AccessionPrimary (citable) accession number: Q9K9B2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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