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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-2883-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:BH2814
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669981 – 488Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ9K936

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2814

Structurei

3D structure databases

ProteinModelPortaliQ9K936
SMRiQ9K936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RGW Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNKDQALIF ELSKPGRVGH SLPELDVLEQ PVETLIPAEF LREEAPELPE
60 70 80 90 100
VSELQLMRHY TALSKRNHGV DSGFYPLGSC TMKYNPKINE DVARYPGFAN
110 120 130 140 150
IHPYQPEAQV QGALRLMYEL QTALAEITGM DEVTLQPAAG AQGEWTGLML
160 170 180 190 200
IRAYHEANGD TNRTKVIVPD SAHGTNPASA TVAGFESVTV RTDEDGLVDL
210 220 230 240 250
DHLREVVGED TAALMLTNPN TLGLFEAHIV EMAAIIHEAG GKLYYDGANS
260 270 280 290 300
NAILGIARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKKELIPYLP
310 320 330 340 350
KPVVVKDGDS YRLDYDRPHS IGRVKPYYGN FGINVRAYTY IRTMGPEGLR
360 370 380 390 400
TVSEYAVLNA NYMMRRLAPY FDLPYDQHCK HEFVLSGRQQ KKLGVRTLDI
410 420 430 440 450
AKRLLDFGYH PPTIYFPLNV EECLMIEPTE TESKETLDEF IEAMIQIAKE
460 470 480
AEETPEVVQE APHHTVIGRL DETTAARKPI LRYEKITQ
Length:488
Mass (Da):54,224
Last modified:October 1, 2000 - v1
Checksum:i1CBACE20B74140E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB06533.1
PIRiF84001
RefSeqiWP_010898962.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB06533; BAB06533; BAB06533
KEGGibha:BH2814

Entry informationi

Entry nameiGCSPB_BACHD
AccessioniPrimary (citable) accession number: Q9K936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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