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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciBHAL272558:G1G3A-2884-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:BH2815
OrganismiBacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
Taxonomic identifieri272558 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001258 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669581 – 447Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST447

Proteomic databases

PRIDEiQ9K935

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi272558.BH2815

Structurei

3D structure databases

ProteinModelPortaliQ9K935
SMRiQ9K935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108JEM Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9K935-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHRYLPMTT DDRQEMLQAI GVDSIEELFS DIPQDIRFKG KLNIPNALKE
60 70 80 90 100
PELIRYFQQL ANENVHLKDK ASFLGAGVYD HYIPSIVDHV ISRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MICELTGMEV ANSSMYDGPT ALAEAAMMSC
160 170 180 190 200
GHTKKKKILV SKAVHPEARD VLMTNAYGQR LEVVEIDTNN GVTDVEHLKA
210 220 230 240 250
LYDEETACVI VQHPNFFGRL EPLAEIESVS HQGKATFVVS SNPLALGLLK
260 270 280 290 300
PPGAFGADVV VGDAQPFGIP TQYGGPHCGY FATTKKLMRK VPGRLVGQTT
310 320 330 340 350
DDQGQRGFVL TLQAREQHIR REKATSNICS NQALNALAAA VAMATIGKRG
360 370 380 390 400
VKEMALQNVQ KAAYAKSQLK ANGVEIVAEG PCFNEFIIKL SSPLHEVEEA
410 420 430 440
LLAKGFIAGY DLGKVYPELE GHMLVAVTEV RTKEEIDQFA KEVGMFA
Length:447
Mass (Da):49,225
Last modified:October 1, 2000 - v1
Checksum:i84C9C126980A937A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000004 Genomic DNA Translation: BAB06534.1
PIRiG84001
RefSeqiWP_010898963.1, NC_002570.2

Genome annotation databases

EnsemblBacteriaiBAB06534; BAB06534; BAB06534
KEGGibha:BH2815

Similar proteinsi

Entry informationi

Entry nameiGCSPA_BACHD
AccessioniPrimary (citable) accession number: Q9K935
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health