Reviewed, UniProtKB/Swiss-Prot Q9K934 (GCST_BACHD)

Names and origin

Protein names

Recommended name:
    Aminomethyltransferase
    EC=2.1.2.10
Alternative name(s):
    Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BH2816

Organism

Bacillus halodurans [Complete proteome] [HAMAP]

Taxonomic identifier

86665 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. HAMAP MF_00259
Sequence similarities	Belongs to the gcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: HAMAP transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Aminomethyltransferase HAMAP MF_00259		PRO_0000122540

Sequences

	Sequence		Length	Mass (Da)
	Q9K934-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 867214D42B3691C5	FASTA	365	40,309
	10 20 30 40 50 60 MTELKKTPLF DLYEQYGGKV IDFGGWALPV QFSSIKEEHE AVRTKAGLFD VSHMGEVEVT 70 80 90 100 110 120 GAQALNYLQR LVTNDVSKIK DGQAQYTAMC YENGGTVDDL LIYRRSEDQY LLVINAANID 130 140 150 160 170 180 KDIAWMEKHA IDGVSITNVS NQTAQLALQG PVAENVLQTL TEEPLADIKF FRFVDGVNIA 190 200 210 220 230 240 GVNVLLSRTG YTGEDGFELY CLAEDAPVLW KKLIEAGKEH GVVPCGLGAR DTLRFEAKLP 250 260 270 280 290 300 LYGQELTKDI SPIEAGIGFA VKVDKEDFIG KEILKKQKEQ GAPRKLVGLE MVDKGIPRTG 310 320 330 340 350 360 YEVYVDNQKI GFVTTGTQSP TLKKNVGLAL LQAEHSELGT EVIVHVRKRQ LIAKVVATPF YKRGN

References

[1]

"Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis." Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K. Nucleic Acids Res. 28:4317-4331(2000) [PubMed: 11058132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-125 / C-125 / DSM 18197 / FERM 7344 / JCM 9153.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000004 Genomic DNA. Translation: BAB06535.1.
PIR	H84001.
RefSeq	NP_243682.1.
3D structure databases
SMR	Q9K934. Positions 4-363.
ModBase	Search...
Genome annotation databases
GeneID	893338.
GenomeReviews	Gene locus BH2816 in contig BA000004_GR.
KEGG	bha:BH2816.
NMPDR	fig|272558.1.peg.2816.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	LMTNDIN.
PhylomeDB	Q9K934.
Enzyme and pathway databases
BioCyc	BHAL272558:BH2816-MONOMER.
BRENDA	2.1.2.10. 191865.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. gcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACHD

Accession

Primary (citable) accession number: Q9K934

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)